Invasive coronary imaging of inflammation to further characterize high-risk lesions: what options do we have?

Autor:	Los J; Department of Cardiology, Radboud University Medical Center, Nijmegen, Netherlands., Mensink FB; Department of Cardiology, Radboud University Medical Center, Nijmegen, Netherlands., Mohammadnia N; Department of Cardiology, Radboud University Medical Center, Nijmegen, Netherlands., Opstal TSJ; Department of Cardiology, Radboud University Medical Center, Nijmegen, Netherlands.; Department of Cardiology, Northwest Clinics, Alkmaar, Netherlands., Damman P; Department of Cardiology, Radboud University Medical Center, Nijmegen, Netherlands., Volleberg RHJA; Department of Cardiology, Radboud University Medical Center, Nijmegen, Netherlands., Peeters DAM; Department of Cardiology, Radboud University Medical Center, Nijmegen, Netherlands., van Royen N; Department of Cardiology, Radboud University Medical Center, Nijmegen, Netherlands., Garcia-Garcia HM; Department of Cardiology, MedStar Washington Hospital Center, Washington, DC, United States., Cornel JH; Department of Cardiology, Radboud University Medical Center, Nijmegen, Netherlands.; Department of Cardiology, Northwest Clinics, Alkmaar, Netherlands.; Dutch Network for Cardiovascular Research (WCN), Utrecht, Netherlands., El Messaoudi S; Department of Cardiology, Radboud University Medical Center, Nijmegen, Netherlands., van Geuns RM; Department of Cardiology, Radboud University Medical Center, Nijmegen, Netherlands.
Jazyk:	angličtina
Zdroj:	Frontiers in cardiovascular medicine [Front Cardiovasc Med] 2024 Feb 01; Vol. 11, pp. 1352025. Date of Electronic Publication: 2024 Feb 01 (Print Publication: 2024).
DOI:	10.3389/fcvm.2024.1352025
Abstrakt:	Coronary atherosclerosis remains a leading cause of morbidity and mortality worldwide. The underlying pathophysiology includes a complex interplay of endothelial dysfunction, lipid accumulation and inflammatory pathways. Multiple structural and inflammatory features of the atherosclerotic lesions have become targets to identify high-risk lesions. Various intracoronary imaging devices have been developed to assess the morphological, biocompositional and molecular profile of the intracoronary atheromata. These techniques guide interventional and therapeutical management and allow the identification and stratification of atherosclerotic lesions. We sought to provide an overview of the inflammatory pathobiology of atherosclerosis, distinct high-risk plaque features and the ability to visualize this process with contemporary intracoronary imaging techniques. Competing Interests: PD: received research grants and speaker fees from Abbott Vascular; research grants, speaker fees and consultancy fees from Philips; and research grants from AstraZeneca. NvR: research grants from Abbott, Philpis, Biotronik and Medtronic. Speaker fee: Abbott, Bayer, Rainmed, Microport. HG-G: receives consulting fees from Boston Scientific, Abbott and institutional grants from Phillips, Biotronik, Abbott, MedAlliance, Corflow, Chiesi and Medis. JC: Advisory board Amgen en Novo Nordisk. Received research grants from ZonMw. R-JvG: reported grants and personal fees from Boston Scientific, grants and personal fees from Abbott Vascular, grants and personal fees from Astra Zeneca, grants and personal fees from Amgen, grants from InfraRedx. The other authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (© 2024 Los, Mensink, Mohammadnia, Opstal, Damman, Volleberg, Peeters, van Royen, Garcia-Garcia, Cornel, El Messaoudi and van Geuns.)
Databáze:	MEDLINE
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