Assessment of the Cutaneous Hormone Landscapes and Microbiomes in Vulvar Lichen Sclerosus.

Autor:	Pyle HJ; Department of Dermatology, The University of Texas Southwestern Medical Center, Dallas, Texas, USA., Evans JC; Department of Dermatology, The University of Texas Southwestern Medical Center, Dallas, Texas, USA., Artami M; Department of Dermatology, The University of Texas Southwestern Medical Center, Dallas, Texas, USA., Raj P; Department of Immunology, The University of Texas Southwestern Medical Center, Dallas, Texas, USA., Sridharan S; Department of Immunology, The University of Texas Southwestern Medical Center, Dallas, Texas, USA., Arana C; Department of Immunology, The University of Texas Southwestern Medical Center, Dallas, Texas, USA., Eckert KM; Center for Human Nutrition, The University of Texas Southwestern Medical Center, Dallas, Texas, USA; Department of Molecular Genetics, The University of Texas Southwestern Medical Center, Dallas, Texas, USA., McDonald JG; Center for Human Nutrition, The University of Texas Southwestern Medical Center, Dallas, Texas, USA; Department of Molecular Genetics, The University of Texas Southwestern Medical Center, Dallas, Texas, USA., Harris-Tryon TA; Department of Dermatology, The University of Texas Southwestern Medical Center, Dallas, Texas, USA. Electronic address: tamia.harris-tryon@utsouthwestern.edu., Mauskar MM; Department of Dermatology, The University of Texas Southwestern Medical Center, Dallas, Texas, USA. Electronic address: melissa.mauskar@utsouthwestern.edu.
Jazyk:	angličtina
Zdroj:	The Journal of investigative dermatology [J Invest Dermatol] 2024 Aug; Vol. 144 (8), pp. 1808-1816.e11. Date of Electronic Publication: 2024 Feb 17.
DOI:	10.1016/j.jid.2024.01.027
Abstrakt:	Vulvar lichen sclerosus (VLS) is a progressive skin disease of unknown etiology. In this longitudinal case-control exploratory study, we evaluated the hormonal and microbial landscapes in 18 postmenopausal females (mean [SD] age: 64.4 [8.4] years) with VLS and controls. We reevaluated the patients with VLS after 10-14 weeks of daily topical class I steroid. We found that groin cutaneous estrone was lower in VLS than in controls (-22.33, 95% confidence interval [CI] = -36.96 to -7.70; P = .006); cutaneous progesterone was higher (5.73, 95% CI = 3.74-7.73; P < .0001). Forehead 11-deoxycortisol (-0.24, 95% CI = -0.42 to -0.06; P = .01) and testosterone (-7.22, 95% CI = -12.83 to -1.62; P = .02) were lower in disease. With treatment, cutaneous estrone (-7.88, 95% CI = -44.07 to 28.31; P = .62), progesterone (2.02, 95% CI = -2.08 to 6.11; P = .29), and 11-deoxycortisol (-0.13, 95% CI = -0.32 to 0.05; P = .15) normalized; testosterone remained suppressed (-7.41, 95% CI = -13.38 to -1.43; P = .02). 16S ribosomal RNA V1-V3 and ITS1 amplicon sequencing revealed bacterial and fungal microbiome alterations in disease. Findings suggest that cutaneous sex hormone and bacterial microbiome alterations may be associated with VLS in postmenopausal females. (Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu