Protective efficacy of a Zika purified inactivated virus vaccine candidate during pregnancy in marmosets.

Autor: Kim IJ; Trudeau Institute, Inc., Saranac Lake, NY, 12983, USA. ijkim@trudeauinstitute.org., Gonzalez O; Southwest National Primate Center, Texas Biomedical Research Institute, San Antonio, TX, 78227, USA., Tighe MP; Trudeau Institute, Inc., Saranac Lake, NY, 12983, USA., Lanthier PA; Trudeau Institute, Inc., Saranac Lake, NY, 12983, USA., Clark MJ; Trudeau Institute, Inc., Saranac Lake, NY, 12983, USA., Travis KL; Trudeau Institute, Inc., Saranac Lake, NY, 12983, USA., Low-Beer TC; Trudeau Institute, Inc., Saranac Lake, NY, 12983, USA., Lanzer KG; Trudeau Institute, Inc., Saranac Lake, NY, 12983, USA., Bernacki DT; Trudeau Institute, Inc., Saranac Lake, NY, 12983, USA., Szaba FM; Trudeau Institute, Inc., Saranac Lake, NY, 12983, USA., De La Barrera RA; Pilot Bioproduction Facility, Center for Enabling Capabilities, Walter Reed Army Institute of Research, Silver Spring, MD, 20910, USA., Dussupt V; Emerging Infectious Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, MD, 20910, USA.; U.S. Military HIV Research Program, Center of Infectious Disease Research, Walter Reed Army Institute of Research, Silver Spring, MD, 20910, USA.; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, 20817, USA., Mendez-Rivera L; Emerging Infectious Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, MD, 20910, USA.; U.S. Military HIV Research Program, Center of Infectious Disease Research, Walter Reed Army Institute of Research, Silver Spring, MD, 20910, USA.; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, 20817, USA., Krebs SJ; Emerging Infectious Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, MD, 20910, USA.; U.S. Military HIV Research Program, Center of Infectious Disease Research, Walter Reed Army Institute of Research, Silver Spring, MD, 20910, USA.; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, 20817, USA., Ross CN; Southwest National Primate Center, Texas Biomedical Research Institute, San Antonio, TX, 78227, USA., Mdaki SD; Southwest National Primate Center, Texas Biomedical Research Institute, San Antonio, TX, 78227, USA.; Science and Technology, Joint Base San Antonio-Fort Sam AFB, San Antonio, TX, 78236, USA., Brasky KM; Southwest National Primate Center, Texas Biomedical Research Institute, San Antonio, TX, 78227, USA., Layne-Colon D; Southwest National Primate Center, Texas Biomedical Research Institute, San Antonio, TX, 78227, USA., Tardif SD; Southwest National Primate Center, Texas Biomedical Research Institute, San Antonio, TX, 78227, USA., Thomas SJ; Institute for Global Health and Translational Sciences, State University of New York, Upstate Medical University, Syracuse, NY, 13210, USA., Modjarrad K; Emerging Infectious Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, MD, 20910, USA.; Pfizer Inc. Vaccine Research and Development, Pearl River, NY, 10965, USA., Blackman MA; Trudeau Institute, Inc., Saranac Lake, NY, 12983, USA., Patterson JL; Southwest National Primate Center, Texas Biomedical Research Institute, San Antonio, TX, 78227, USA. jpatters@txbiomed.org.
Jazyk: angličtina
Zdroj: NPJ vaccines [NPJ Vaccines] 2024 Feb 17; Vol. 9 (1), pp. 35. Date of Electronic Publication: 2024 Feb 17.
DOI: 10.1038/s41541-024-00824-0
Abstrakt: Zika virus (ZIKV) infection during pregnancy poses significant threats to maternal and fetal health, leading to intrauterine fetal demise and severe developmental malformations that constitute congenital Zika syndrome (CZS). As such, the development of a safe and effective ZIKV vaccine is a critical public health priority. However, the safety and efficacy of such a vaccine during pregnancy remain uncertain. Historically, the conduct of clinical trials in pregnant women has been challenging. Therefore, clinically relevant animal pregnancy models are in high demand for testing vaccine efficacy. We previously reported that a marmoset pregnancy model of ZIKV infection consistently demonstrated vertical transmission from mother to fetus during pregnancy. Using this marmoset model, we also showed that vertical transmission could be prevented by pre-pregnancy vaccination with Zika purified inactivated virus (ZPIV) vaccine. Here, we further examined the efficacy of ZPIV vaccination during pregnancy. Vaccination during pregnancy elicited virus neutralizing antibody responses that were comparable to those elicited by pre-pregnancy vaccination. Vaccination also reduced placental pathology, viral burden and vertical transmission of ZIKV during pregnancy, without causing adverse effects. These results provide key insights into the safety and efficacy of ZPIV vaccination during pregnancy and demonstrate positive effects of vaccination on the reduction of ZIKV infection, an important advance in preparedness for future ZIKV outbreaks.
(© 2024. The Author(s).)
Databáze: MEDLINE
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