Atypical plaque psoriasis: a clinicopathological study of 20 cases.

Autor: Luo SY; The First Affiliated Hospital of Chongqing Medical University, Chongqing, China., Zhou KY; The First Affiliated Hospital of Chongqing Medical University, Chongqing, China., Wang QX; The First Affiliated Hospital of Chongqing Medical University, Chongqing, China., Deng LJ; The First Affiliated Hospital of Chongqing Medical University, Chongqing, China., Fang S; The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Jazyk: angličtina
Zdroj: International journal of dermatology [Int J Dermatol] 2024 Aug; Vol. 63 (8), pp. 1041-1047. Date of Electronic Publication: 2024 Feb 17.
DOI: 10.1111/ijd.17063
Abstrakt: Background: Plaque psoriasis is relatively straightforward to identify. When diagnostic concerns arise in atypical cases, a biopsy is needed. It is widely accepted that the Munro microabscess and the spongiform pustule of Kogoj are diagnostic pathological features. However, the diagnostic dilemma is likely to arise in cases without these specific pathological changes and typical clinical features. This study aimed to investigate clinical and pathological clues in distinguishing atypical plaque psoriasis from its mimics.
Methods: We evaluated the clinicopathological features of 20 cases of atypical plaque psoriasis and 40 cases of psoriasis mimics as controls including pityriasis rosea (n = 10), pityriasis lichenoides chronica (n = 8), and subacute dermatitis (n = 22).
Results: A retrospective analysis of the clinicopathological characteristics of patients with atypical plaque psoriasis and controls was performed. Pathologically, there were significant differences between the two groups in the types of parakeratosis (P = 0.046), epidermal capture of extravasated erythrocytes (P = 0.011), focal basal liquefied degeneration (P = 0.017), types of inflammatory cells (P = 0.000), and depth of inflammation (P = 0.000). Clinically, we found the presence of scales and crusts was significantly different between the two groups.
Conclusion: This study offers insight into the clinicopathological features of atypical plaque psoriasis. These differential diagnostic features, compared with its mimics, are proposed to assist the clinician in the diagnosis and treatment of atypical plaque psoriasis.
(© 2024 the International Society of Dermatology.)
Databáze: MEDLINE
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