α-Viniferin, a dietary phytochemical, inhibits Monoamine oxidase and alleviates Parkinson's disease associated behavioral deficits in a mice model.

Autor: Banerjee C; Cell Biology and Physiology Division, CSIR- Indian Institute of Chemical Biology, Kolkata- 700032, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad- 201002, India., Barman R; Organic and Medicinal Chemistry Division, CSIR-Indian Institute of Chemical Biology, Kolkata- 700032, India., Darshani P; Organic and Medicinal Chemistry Division, CSIR-Indian Institute of Chemical Biology, Kolkata- 700032, India., Pillai M; Cell Biology and Physiology Division, CSIR- Indian Institute of Chemical Biology, Kolkata- 700032, India., Ahuja S; Cell Biology and Physiology Division, CSIR- Indian Institute of Chemical Biology, Kolkata- 700032, India., Mondal R; Cell Biology and Physiology Division, CSIR- Indian Institute of Chemical Biology, Kolkata- 700032, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad- 201002, India., Pragadheesh VS; CSIR-Central Institute of Medicinal and Aromatic Plants, Research Centre, Bengaluru- 560065, India., Chakraborty J; Cell Biology and Physiology Division, CSIR- Indian Institute of Chemical Biology, Kolkata- 700032, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad- 201002, India. Electronic address: joy.chakraborty@iicb.res.in., Kumar D; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad- 201002, India; Organic and Medicinal Chemistry Division, CSIR-Indian Institute of Chemical Biology, Kolkata- 700032, India. Electronic address: deepak@iicb.res.in.
Jazyk: angličtina
Zdroj: Neurochemistry international [Neurochem Int] 2024 Mar; Vol. 174, pp. 105698. Date of Electronic Publication: 2024 Feb 15.
DOI: 10.1016/j.neuint.2024.105698
Abstrakt: Parkinson's disease (PD) is one of the most prevalent age-related neurodegenerative disorders. Behavioral complexities worsen over time due to progressive dopaminergic (DArgic) neuronal loss at substantia nigra region of brain. Available treatments typically aim to increase dopamine (DA) levels at striatum. DA is degraded by Monoamine oxidase (MAO), thus dietary phytochemicals with MAO inhibitory properties can contribute to elevate DA levels and reduce the ailment. Characterization of naturally occurring dietary MAO inhibitors is inadequate. Based on available knowledge, we selected different classes of molecules and conducted a screening process to assess their potential as MAO inhibitors. The compounds mostly derived from food sources, broadly belonging to triterpenoids (ursane, oleanane and hopane), alkaloid, polyphenolics, monoterpenoids, alkylbenzene, phenylpropanoid and aromatic alcohol classes. Among all the molecules, highest level of MAO inhibition is offered by α-viniferin, a resveratrol trimer. Cell viability, mitochondrial morphology and reactive oxygen species (ROS) generation remained unaltered by 50 μM α-viniferin treatment in-vitro. Toxicity studies in Drosophila showed unchanged gross neuronal morphology, ROS level, motor activity or long-term survival. α-Viniferin inhibited MAO in mice brain and elevated striatal DA levels. PD-related akinesia and cataleptic behavior were attenuated by α-viniferin due to increase in striatal DA. Our study implies that α-viniferin can be used as an adjunct phytotherapeutic agent for mitigating PD-related behavioral deterioration.
Competing Interests: Declaration of competing interest None.
(Copyright © 2024 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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