Naturally acquired immunity to Plasmodium pitheci in Bornean orangutans ( Pongo pygmaeus ).

Autor:	Sánchez KL; IAR Indonesia Foundation, Yayasan Inisiasi Alam Rehabilitasi Indonesia (YIARI), Sinarwangi, Bogor, West Java, Indonesia.; International Animal Rescue, Uckfield, UK.; School of Veterinary Medicine, Freie Universität, Berlin, Germany., Baird JK; Oxford University Clinical Research Unit-Indonesia, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Nielsen A; Center for Law and Economics, ETH Zurich, Zurich, Switzerland., Nurillah A; IAR Indonesia Foundation, Yayasan Inisiasi Alam Rehabilitasi Indonesia (YIARI), Sinarwangi, Bogor, West Java, Indonesia., Agustina F; IAR Indonesia Foundation, Yayasan Inisiasi Alam Rehabilitasi Indonesia (YIARI), Sinarwangi, Bogor, West Java, Indonesia., Komara; IAR Indonesia Foundation, Yayasan Inisiasi Alam Rehabilitasi Indonesia (YIARI), Sinarwangi, Bogor, West Java, Indonesia., Fadilah F; IAR Indonesia Foundation, Yayasan Inisiasi Alam Rehabilitasi Indonesia (YIARI), Sinarwangi, Bogor, West Java, Indonesia., Prameswari W; IAR Indonesia Foundation, Yayasan Inisiasi Alam Rehabilitasi Indonesia (YIARI), Sinarwangi, Bogor, West Java, Indonesia., Nugraha RTP; Research Center for Applied Zoology, National Research and Innovation Agency (BRIN), Jakarta, Indonesia., Saputra S; Research Center for Applied Zoology, National Research and Innovation Agency (BRIN), Jakarta, Indonesia., Nurkanto A; Research Center for Biosystematics and Evolution, National Research and Innovation Agency (BRIN), Jakarta, Indonesia., Dharmayanthi AB; Research Center for Biosystematics and Evolution, National Research and Innovation Agency (BRIN), Jakarta, Indonesia., Pratama R; Center for Biomedical Research, Research Organization for Health, National Research and Innovation Agency (BRIN), Jakarta, Indonesia., Exploitasia I; Biodiversity Conservation Directorate of the General Director of Natural Resources and Ecosystem Conservation, Ministry of Environment and Forestry of the Republic of Indonesia, Jakarta, Indonesia., Greenwood AD; School of Veterinary Medicine, Freie Universität, Berlin, Germany.; Department of Wildlife Diseases, Leibniz Institute for Zoo and Wildlife Research, Berlin, Germany.
Jazyk:	angličtina
Zdroj:	Parasitology [Parasitology] 2024 Apr; Vol. 151 (4), pp. 380-389. Date of Electronic Publication: 2024 Feb 16.
DOI:	10.1017/S0031182024000155
Abstrakt:	Naturally acquired immunity to the different types of malaria in humans occurs in areas of endemic transmission and results in asymptomatic infection of peripheral blood. The current study examined the possibility of naturally acquired immunity in Bornean orangutans, Pongo pygmaeus , exposed to endemic Plasmodium pitheci malaria. A total of 2140 peripheral blood samples were collected between January 2017 and December 2022 from a cohort of 135 orangutans housed at a natural forested Rescue and Rehabilitation Centre in West Kalimantan, Indonesia. Each individual was observed for an average of 4.3 years during the study period. Blood samples were examined by microscopy and polymerase chain reaction for the presence of plasmodial parasites. Infection rates and parasitaemia levels were measured among age groups and all 20 documented clinical malaria cases were reviewed to estimate the incidence of illness and risk ratios among age groups. A case group of all 17 individuals that had experienced clinical malaria and a control group of 34 individuals having an event of >2000 parasites μL −1 blood but with no outward or clinical sign of illness were studied. Immature orangutans had higher-grade and more frequent parasitaemia events, but mature individuals were more likely to suffer from clinical malaria than juveniles. The case orangutans having patent clinical malaria were 256 times more likely to have had no parasitaemia event in the prior year relative to asymptomatic control orangutans. The findings are consistent with rapidly acquired immunity to P. pitheci illness among orangutans that wanes without re-exposure to the pathogen.
Databáze:	MEDLINE
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