Smoking changes adaptive immunity with persistent effects.

Autor: Saint-André V; Translational Immunology Unit, Department of Immunology, Institut Pasteur, Université Paris Cité, Paris, France. violaine.saint-andre@pasteur.fr.; Institut Pasteur, Université Paris Cité, Bioinformatics and Biostatistics Hub, Paris, France. violaine.saint-andre@pasteur.fr., Charbit B; Cytometry and Biomarkers UTechS, Center for Translational Research, Institut Pasteur, Université Paris Cité, Paris, France., Biton A; Institut Pasteur, Université Paris Cité, Bioinformatics and Biostatistics Hub, Paris, France., Rouilly V; DATACTIX, Paris, France., Possémé C; Translational Immunology Unit, Department of Immunology, Institut Pasteur, Université Paris Cité, Paris, France., Bertrand A; Translational Immunology Unit, Department of Immunology, Institut Pasteur, Université Paris Cité, Paris, France.; Frontiers of Innovation in Research and Education PhD Program, LPI Doctoral School, Université Paris Cité, Paris, France., Rotival M; Institut Pasteur, Université Paris Cité, CNRS UMR2000, Human Evolutionary Genetics Unit, Paris, France., Bergstedt J; Institut Pasteur, Université Paris Cité, CNRS UMR2000, Human Evolutionary Genetics Unit, Paris, France.; Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Patin E; Institut Pasteur, Université Paris Cité, CNRS UMR2000, Human Evolutionary Genetics Unit, Paris, France., Albert ML; Octant Biosciences, San Francisco, CA, USA., Quintana-Murci L; Institut Pasteur, Université Paris Cité, CNRS UMR2000, Human Evolutionary Genetics Unit, Paris, France.; Chair Human Genomics and Evolution, Collège de France, Paris, France., Duffy D; Translational Immunology Unit, Department of Immunology, Institut Pasteur, Université Paris Cité, Paris, France. darragh.duffy@pasteur.fr.; Cytometry and Biomarkers UTechS, Center for Translational Research, Institut Pasteur, Université Paris Cité, Paris, France. darragh.duffy@pasteur.fr.
Jazyk: angličtina
Zdroj: Nature [Nature] 2024 Feb; Vol. 626 (8000), pp. 827-835. Date of Electronic Publication: 2024 Feb 14.
DOI: 10.1038/s41586-023-06968-8
Abstrakt: Individuals differ widely in their immune responses, with age, sex and genetic factors having major roles in this inherent variability 1-6 . However, the variables that drive such differences in cytokine secretion-a crucial component of the host response to immune challenges-remain poorly defined. Here we investigated 136 variables and identified smoking, cytomegalovirus latent infection and body mass index as major contributors to variability in cytokine response, with effects of comparable magnitudes with age, sex and genetics. We find that smoking influences both innate and adaptive immune responses. Notably, its effect on innate responses is quickly lost after smoking cessation and is specifically associated with plasma levels of CEACAM6, whereas its effect on adaptive responses persists long after individuals quit smoking and is associated with epigenetic memory. This is supported by the association of the past smoking effect on cytokine responses with DNA methylation at specific signal trans-activators and regulators of metabolism. Our findings identify three novel variables associated with cytokine secretion variability and reveal roles for smoking in the short- and long-term regulation of immune responses. These results have potential clinical implications for the risk of developing infections, cancers or autoimmune diseases.
(© 2024. The Author(s).)
Databáze: MEDLINE
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