Enhanced Inhibition of Cancer Cell Migration by a Planar Catechin Analog.

Autor:	Ito H; Quantum RedOx Chemistry Team, Institute for Quantum Life Science (iQLS), Quantum Life and Medical Science Directorate (QLMS), National Institutes for Quantum Science and Technology (QST), Chiba 263-8555, Japan., Shoji Y; Quantum RedOx Chemistry Team, Institute for Quantum Life Science (iQLS), Quantum Life and Medical Science Directorate (QLMS), National Institutes for Quantum Science and Technology (QST), Chiba 263-8555, Japan.; Quantitative RedOx Sensing Group, Department of Radiation Regulatory Science Research, Institute for Radiological Sciences (NIRS), Quantum Life and Medical Science Directorate (QLMS), National Institutes for Quantum Science and Technology (QST), Chiba 263-8555, Japan., Matsumoto KI; Quantitative RedOx Sensing Group, Department of Radiation Regulatory Science Research, Institute for Radiological Sciences (NIRS), Quantum Life and Medical Science Directorate (QLMS), National Institutes for Quantum Science and Technology (QST), Chiba 263-8555, Japan., Fukuhara K; Division of Medicinal Chemistry, Department of Pharmaceutical Sciences, Showa University School of Pharmacy, Tokyo 142-8555, Japan., Nakanishi I; Quantum RedOx Chemistry Team, Institute for Quantum Life Science (iQLS), Quantum Life and Medical Science Directorate (QLMS), National Institutes for Quantum Science and Technology (QST), Chiba 263-8555, Japan.
Jazyk:	angličtina
Zdroj:	ACS medicinal chemistry letters [ACS Med Chem Lett] 2024 Jan 10; Vol. 15 (2), pp. 310-313. Date of Electronic Publication: 2024 Jan 10 (Print Publication: 2024).
DOI:	10.1021/acsmedchemlett.3c00499
Abstrakt:	Cancer cell migration is related to malignancy and patient prognosis. We previously reported that intracellular reactive oxygen species (ROS) promoted cancer cellular migration and invasion and that an antioxidant enzyme could help to attenuate the malignancy. Catechin is known as an antioxidant, and we have developed a catechin analog, planar catechin, which showed an antioxidant activity significantly stronger than that of the parent (+)-catechin. In this study, we examined the effects of the planar catechin on the migration of gastric normal and cancer cells. A scratched assay showed that the planar catechin suppressed the cellular migration rates in both normal and cancer cells, while the prevention levels in cancer cells were remarkable compared to the normal cells. These results suggest that the planar catechin with the enhanced antioxidant activity effectively scavenged the ROS overexpressed in the cancer cells and inhibited cancer cellular activities, including migration. Competing Interests: The authors declare no competing financial interest. (© 2024 American Chemical Society.)
Databáze:	MEDLINE
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