Nanoformulated meloxicam and rifampin: inhibiting quorum sensing and biofilm formation in Pseudomonas aeruginosa .

Autor:	Khorramdel M; Department of Microbiology, Ayatollah Amoli Branch, Islamic Azad University, Amol, Iran., Ghadikolaii FP; Department of Biology, Qaemshahr Branch, Islamic Azad University, Qaemshahr, Iran., Hashemy SI; Surgical Oncology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.; Department of Clinical Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran., Javid H; Surgical Oncology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.; Department of Clinical Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.; Department of Medical Laboratory Sciences, Varastegan Institute for Medical Sciences, Mashhad, Iran., Tabrizi MH; Department of Biology, Mashhad Branch, Islamic Azad University, Mashhad, Iran.
Jazyk:	angličtina
Zdroj:	Nanomedicine (London, England) [Nanomedicine (Lond)] 2024 Mar; Vol. 19 (7), pp. 615-632. Date of Electronic Publication: 2024 Feb 13.
DOI:	10.2217/nnm-2023-0268
Abstrakt:	Background: We aimed to investigate the simultaneous effects of meloxicam and rifampin nanoformulations with solid lipid nanoparticle (SLN) and nanostructured lipid carrier (NLC) substrates on inhibiting the quorum-sensing system of Pseudomonas aeruginosa and preventing biofilm formation by this bacterium. Methods: Antimicrobial activity of rifampin and meloxicam encapsulated with SLNs and NLCs against P. aeruginosa PAO1 was assessed by disk diffusion, minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC). Results: The SLN formulation was associated with lower doses for the MIC and minimum bactericidal concentration in comparison to NLC. Moreover, our results demonstrated that both nanoformulations were able to produce 100% inhibition of the biofilm formation of P. aeruginosa PAO1. Conclusion: All these findings suggest that meloxicam and rifampin encapsulated with SLNs could be the most effective formulation against P. aeruginosa .
Databáze:	MEDLINE
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