T1 hypointense brain lesions in NMOSD and its relevance with disability: a single institution cross-sectional study.

Autor: Ghazanfari Hashemi M; Multiple Sclerosis Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Neurology Department, Sina Hospital, Tehran, Iran., Talebi V; Multiple Sclerosis Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Neurology Department, Sina Hospital, Tehran, Iran., Abbasi Kasbi N; Multiple Sclerosis Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Neurology Department, Sina Hospital, Tehran, Iran., Abbasi M; Department of Nuclear Medicine, Vali-Asr Hospital, Tehran University of Medical Sciences, Tehran, Iran., Asgari N; Department of Neurology, Institutes of Regional Health Research and Molecular Medicine, University of Southern Denmark, Odense, Denmark., Sahraian MA; Multiple Sclerosis Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Neurology Department, Sina Hospital, Tehran, Iran. Sahraian1350@yahoo.com.
Jazyk: angličtina
Zdroj: BMC neurology [BMC Neurol] 2024 Feb 12; Vol. 24 (1), pp. 62. Date of Electronic Publication: 2024 Feb 12.
DOI: 10.1186/s12883-024-03550-1
Abstrakt: Background: T1 hypointense lesions are considered a surrogate marker of tissue destruction. Although there is a shortage of evidence about T1 hypointense brain lesions, black holes, in patients with Neuromyelitis Optica Spectrum Disorder (NMOSD), the clinical significance of these lesions is not well determined.
Objectives: The impact of T1 hypointense brain lesions on the clinical status and the disability level of patients with NMOSD was sought in this study.
Methods: A total of 83 patients with the final diagnosis of NMOSD were recruited. Aquaporin-4 measures were collected. The expanded disability status scale (EDSS) and MRI studies were also extracted. T1 hypointense and T2/FLAIR hyperintense lesions were investigated. The correlation of MRI findings, AQP-4, and EDSS was assessed.
Results: T1 hypointense brain lesions were detected in 22 patients. Mean ± SD EDSS was 3.7 ± 1.5 and significantly higher in patients with brain T1 hypointense lesions than those without them (p-value = 0.01). Noticeably, patients with more than four T1 hypointense lesions had EDSS scores ≥ 4. The presence of T2/FLAIR hyperintense brain lesions correlated with EDSS (3.6 ± 1.6 vs 2.3 ± 1.7; p-value = 0.01). EDSS was similar between those with and without positive AQP-4 (2.7 ± 1.6 vs. 3.2 ± 1.7; p-value = 0.17). Also, positive AQP-4 was not more prevalent in patients with T1 hypointense brain lesions than those without them (50.9 vs 45.4%; p-value = 0.8).
Conclusion: We demonstrated that the presence of the brain T1-hypointense lesions corresponds to a higher disability level in NMOSD.
(© 2024. The Author(s).)
Databáze: MEDLINE
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