Conversion to faricimab after prior anti-vascular endothelial growth factor therapy for persistent diabetic macular oedema.

Autor:	Durrani AF; Mid Atlantic Retina, Wills Eye Hospital, Philadelphia, Pennsylvania, USA., Momenaei B; Mid Atlantic Retina, Wills Eye Hospital, Philadelphia, Pennsylvania, USA., Wakabayashi T; Mid Atlantic Retina, Wills Eye Hospital, Philadelphia, Pennsylvania, USA., Vemula S; Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, Pennsylvania, USA., Pandit SA; Mid Atlantic Retina, Wills Eye Hospital, Philadelphia, Pennsylvania, USA., Hsu J; Mid Atlantic Retina, Wills Eye Hospital, Philadelphia, Pennsylvania, USA., Ho AC; Mid Atlantic Retina, Wills Eye Hospital, Philadelphia, Pennsylvania, USA., Spirn MJ; Mid Atlantic Retina, Wills Eye Hospital, Philadelphia, Pennsylvania, USA., Klufas MA; Mid Atlantic Retina, Wills Eye Hospital, Philadelphia, Pennsylvania, USA., Garg SJ; Mid Atlantic Retina, Wills Eye Hospital, Philadelphia, Pennsylvania, USA., Vander JF; Mid Atlantic Retina, Wills Eye Hospital, Philadelphia, Pennsylvania, USA., Regillo CD; Mid Atlantic Retina, Wills Eye Hospital, Philadelphia, Pennsylvania, USA., Chiang A; Mid Atlantic Retina, Wills Eye Hospital, Philadelphia, Pennsylvania, USA., Kuriyan AE; Mid Atlantic Retina, Wills Eye Hospital, Philadelphia, Pennsylvania, USA., Yonekawa Y; Mid Atlantic Retina, Wills Eye Hospital, Philadelphia, Pennsylvania, USA yyonekawa@midatlanticretina.com.
Jazyk:	angličtina
Zdroj:	The British journal of ophthalmology [Br J Ophthalmol] 2024 Aug 22; Vol. 108 (9), pp. 1257-1262. Date of Electronic Publication: 2024 Aug 22.
DOI:	10.1136/bjo-2023-324394
Abstrakt:	Background: To assess the anatomical and functional outcomes in eyes with persistent diabetic macular oedema (pDME) on chronic anti-vascular endothelial growth factor therapy switched to intravitreal faricimab. Methods: Patients with pDME on chronic anti-vascular endothelial growth factor therapy that were switched to faricimab and received at least three injections at our institution between April 2022 and May 2023 were included in this study. Patients were excluded if they had complete response to previous treatment but were switched to extend treatment intervals if they had steroid or laser treatment for DME within 6 months prior to switch. Clinical and imaging data were extracted from the electronic medical record. Central foveal thickness (CFT) and Snellen visual acuity (VA) were obtained before and after three intravitreal faricimab injections. Generalised estimating equations were used to analyse the change in CFT and VA. Result: During the study period, 69 eyes of 53 patients met inclusion criteria. The mean age was 68.6±9.0 years. The mean number of injections prior to switch was 18.1±16.0. Pre-switch mean logarithm of the minimal angle of resolution VA was 0.40±0.30 (Snellen equivalent 20/50) and 0.38±0.27 (Snellen equivalent 20/48) after three faricimab injections (p=0.397). Mean CFT improved from 380±155 microns to 323±147 microns (p<0.001). No ophthalmic or systemic adverse events occurred during the study period. Conclusions: Intravitreal faricimab can improve anatomic outcomes while maintaining visual acuity in eyes with pDME previously treated with anti-VEGF therapy. Competing Interests: Competing interests: None declared. (© Author(s) (or their employer(s)) 2024. No commercial re-use. See rights and permissions. Published by BMJ.)
Databáze:	MEDLINE
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