Unraveling diurnal and technical variability in cerebral hemodynamics from neurovascular 4D-Flow MRI.

Autor:	Rivera-Rivera LA; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.; Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.; Department of Medical Physics, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA., Roberts GS; Department of Medical Physics, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA., Peret A; Department of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA., Langhough RE; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.; Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA., Jonaitis EM; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.; Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA., Du L; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.; Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA., Field A; Department of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA., Eisenmenger L; Department of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA., Johnson SC; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.; Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA., Johnson KM; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.; Department of Medical Physics, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Jazyk:	angličtina
Zdroj:	Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism [J Cereb Blood Flow Metab] 2024 Aug; Vol. 44 (8), pp. 1362-1375. Date of Electronic Publication: 2024 Feb 10.
DOI:	10.1177/0271678X241232190
Abstrakt:	Neurovascular 4D-Flow MRI enables non-invasive evaluation of cerebral hemodynamics including measures of cerebral blood flow (CBF), vessel pulsatility index (PI), and cerebral pulse wave velocity (PWV). 4D-Flow measures have been linked to various neurovascular disorders including small vessel disease and Alzheimer's disease; however, physiological and technical sources of variability are not well established. Here, we characterized sources of diurnal physiological and technical variability in cerebral hemodynamics using 4D-Flow in a retrospective study of cognitively unimpaired older adults (N = 750) and a prospective study of younger adults (N = 10). Younger participants underwent repeated MRI sessions at 7am, 4 pm, and 10 pm. In the older cohort, having an MRI earlier on the day was significantly associated with higher CBF and lower PI. In prospective experiments, time of day significantly explained variability in CBF and PI; however, not in PWV. Test-retest experiments showed high CBF intra-session repeatability (repeatability coefficient (RPC) =7.2%), compared to lower diurnal repeatability (RPC = 40%). PI and PWV displayed similar intra-session and diurnal variability (PI intra-session RPC = 22%, RPC = 24% 7am vs 4 pm; PWV intra-session RPC = 17%, RPC = 21% 7am vs 4 pm). Overall, CBF measures showed low technical variability, supporting diurnal variability is from physiology. PI and PWV showed higher technical variability but less diurnal variability. Competing Interests: Declaration of conflicting interestsThe author(s) declared the following potential conflicts of interest with respect to the research, authorship, and/or publication of this article: S.C. Johnson served on an advisory board for Roche Diagnostics in 2018 for which he received an honorarium and is principal investigator of an equipment grant from Roche. He conducts tau imaging in NIH funded studies as well as a study funded by Cerveau Technologies using radioligand precursor material supplied by Cerveau Technologies.
Databáze:	MEDLINE
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