What's new about the tumor microenvironment of urothelial carcinoma?

Autor: Coelho JQ; Unidade Local de Saúde de Santo António, Porto, Portugal. v.joao.q.coelho@gmail.com., Ramos MJ; Unidade Local de Saúde de Santo António, Porto, Portugal., Ranchor R; Unidade Local de Saúde de Santo António, Porto, Portugal., Pichel R; Unidade Local de Saúde de Santo António, Porto, Portugal., Guerra L; Unidade Local de Saúde de Santo António, Porto, Portugal., Miranda H; Unidade Local de Saúde de Santo António, Porto, Portugal., Simões J; Unidade Local de Saúde de Santo António, Porto, Portugal., Azevedo SX; Unidade Local de Saúde de Santo António, Porto, Portugal., Febra J; Unidade Local de Saúde de Santo António, Porto, Portugal., Araújo A; Unidade Local de Saúde de Santo António, Porto, Portugal.; Oncology Research Unit, UMIB - Unit for Multidisciplinary Research in Biomedicine, ICBAS - School of Medicine and Biomedical Sciences, University of Porto, Porto, Portugal.
Jazyk: angličtina
Zdroj: Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico [Clin Transl Oncol] 2024 Jul; Vol. 26 (7), pp. 1549-1560. Date of Electronic Publication: 2024 Feb 08.
DOI: 10.1007/s12094-024-03384-w
Abstrakt: Urothelial carcinoma is a significant global health concern that accounts for a substantial part of cancer diagnoses and deaths worldwide. The tumor microenvironment is a complex ecosystem composed of stromal cells, soluble factors, and altered extracellular matrix, that mutually interact in a highly immunomodulated environment, with a prominent role in tumor development, progression, and treatment resistance. This article reviews the current state of knowledge of the different cell populations that compose the tumor microenvironment of urothelial carcinoma, its main functions, and distinct interactions with other cellular and non-cellular components, molecular alterations and aberrant signaling pathways already identified. It also focuses on the clinical implications of these findings, and its potential to translate into improved quality of life and overall survival. Determining new targets or defining prognostic signatures for urothelial carcinoma is an ongoing challenge that could be accelerated through a deeper understanding of the tumor microenvironment.
(© 2024. The Author(s), under exclusive licence to Federación de Sociedades Españolas de Oncología (FESEO).)
Databáze: MEDLINE
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