Efficacy and safety of transcranial magnetic stimulation on cognition in mild cognitive impairment, Alzheimer's disease, Alzheimer's disease-related dementias, and other cognitive disorders: a systematic review and meta-analysis.

Autor:	Pagali SR; Division of Hospital Internal Medicine, Mayo Clinic, Rochester, MI, USA.; Division of Community Internal Medicine, Geriatrics, and Palliative Care, Mayo Clinic, Rochester, MI, USA., Kumar R; Department of Psychiatry and Psychology, Mayo Clinic School of Graduate Medical Education, Mayo Clinic College of Medicine and Science, Rochester, MI, USA., LeMahieu AM; Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MI, USA., Basso MR; Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MI, USA., Boeve BF; Department of Neurology, Mayo Clinic, Rochester, MI, USA., Croarkin PE; Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MI, USA., Geske JR; Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MI, USA., Hassett LC; Mayo Clinic Libraries, Mayo Clinic, Rochester, MI, USA., Huston J 3rd; Department of Radiology (Huston and Welker), Mayo Clinic, Rochester, MI, USA., Kung S; Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MI, USA., Lundstrom BN; Department of Neurology, Mayo Clinic, Rochester, MI, USA., Petersen RC; Department of Neurology, Mayo Clinic, Rochester, MI, USA., St Louis EK; Department of Neurology, Mayo Clinic, Rochester, MI, USA., Welker KM; Department of Radiology (Huston and Welker), Mayo Clinic, Rochester, MI, USA., Worrell GA; Department of Neurology, Mayo Clinic, Rochester, MI, USA., Pascual-Leone A; Hinda and Arthur Marcus Institute for Aging Research and Deanna, Sidney Wolk Center for Memory Health, Hebrew SeniorLife, Roslindale, MA, USA.; Department of Neurology, Harvard Medical School, Cambridge, MA, USA., Lapid MI; Division of Community Internal Medicine, Geriatrics, and Palliative Care, Mayo Clinic, Rochester, MI, USA.; Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MI, USA.
Jazyk:	angličtina
Zdroj:	International psychogeriatrics [Int Psychogeriatr] 2024 Feb 08, pp. 1-49. Date of Electronic Publication: 2024 Feb 08.
DOI:	10.1017/S1041610224000085
Abstrakt:	Objective: We aim to analyze the efficacy and safety of TMS on cognition in mild cognitive impairment (MCI), Alzheimer's disease (AD), AD-related dementias, and nondementia conditions with comorbid cognitive impairment. Design: Systematic review, Meta-Analysis. Setting: We searched MEDLINE, Embase, Cochrane database, APA PsycINFO, Web of Science, and Scopus from January 1, 2000, to February 9, 2023. Participants and Interventions: RCTs, open-label, and case series studies reporting cognitive outcomes following TMS intervention were included. Measurement: Cognitive and safety outcomes were measured. Cochrane Risk of Bias for RCTs and MINORS (Methodological Index for Non-Randomized Studies) criteria were used to evaluate study quality. This study was registered with PROSPERO (CRD42022326423). Results: The systematic review included 143 studies ( n = 5,800 participants) worldwide, encompassing 94 RCTs, 43 open-label prospective, 3 open-label retrospective, and 3 case series. The meta-analysis included 25 RCTs in MCI and AD. Collectively, these studies provide evidence of improved global and specific cognitive measures with TMS across diagnostic groups. Only 2 studies (among 143) reported 4 adverse events of seizures: 3 were deemed TMS unrelated and another resolved with coil repositioning. Meta-analysis showed large effect sizes on global cognition (Mini-Mental State Examination (SMD = 0.80 [0.26, 1.33], p = 0.003), Montreal Cognitive Assessment (SMD = 0.85 [0.26, 1.44], p = 0.005), Alzheimer's Disease Assessment Scale-Cognitive Subscale (SMD = -0.96 [-1.32, -0.60], p < 0.001)) in MCI and AD, although with significant heterogeneity. Conclusion: The reviewed studies provide favorable evidence of improved cognition with TMS across all groups with cognitive impairment. TMS was safe and well tolerated with infrequent serious adverse events.
Databáze:	MEDLINE
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