The linkage between IL-6 rs1800797 variant and breast cancer susceptibility in Bangladeshi women: A case-control study.

Autor: Khanom M; Department of Pharmacy, Faculty of Science Noakhali Science and Technology University Noakhali Bangladesh., Hossen MS; Department of Pharmacy, Faculty of Science Noakhali Science and Technology University Noakhali Bangladesh., Barek MA; Department of Pharmacy, Faculty of Science Noakhali Science and Technology University Noakhali Bangladesh., Ahamed MS; Department of Pharmacy, Faculty of Science Noakhali Science and Technology University Noakhali Bangladesh., Alam MS; Department of Pharmacy, Faculty of Science Noakhali Science and Technology University Noakhali Bangladesh., Bhowmik KK; Department of Pharmacy, Faculty of Science Noakhali Science and Technology University Noakhali Bangladesh., Jafrin S; Department of Pharmacy, Faculty of Science Noakhali Science and Technology University Noakhali Bangladesh., Aziz MA; Department of Pharmacy, Faculty of Science Noakhali Science and Technology University Noakhali Bangladesh.; Bangladesh Pharmacogenomics Research Network (BdPGRN) Dhaka Bangladesh., Islam MS; Department of Pharmacy, Faculty of Science Noakhali Science and Technology University Noakhali Bangladesh.; Bangladesh Pharmacogenomics Research Network (BdPGRN) Dhaka Bangladesh.
Jazyk: angličtina
Zdroj: Health science reports [Health Sci Rep] 2024 Feb 06; Vol. 7 (2), pp. e1875. Date of Electronic Publication: 2024 Feb 06 (Print Publication: 2024).
DOI: 10.1002/hsr2.1875
Abstrakt: Background and Aims: Breast cancer is one of the deadliest diseases affecting women in Bangladesh, and its prevalence is increasing year by year. Although several IL-6 single nucleotide polymorphisms have been implicated in BC susceptibility and prognosis in various studies, no research has been done to investigate the relationship between breast cancer and IL-6 in Bangladeshi women. This investigation aimed to explore the linkage between the rs1800797 variant of IL-6 and the susceptibility to breast carcinoma among women in Bangladesh.
Methods: The IL-6 rs1800797 variant was genotyped in 218 subjects (110 cases and 108 controls) using the tetra-primer ARMS-PCR method. The statistical analysis was applied utilizing the SPSS software version 24.0. UALCAN database was used for IL-6 mRNA analysis, and genotype-based gene expression was retrieved from GTEx Portal.
Results: This study found a significant link between IL-6 rs1800797 variants and increased chance of breast cancer across different genetic inheritance models, including additive model 1 (AG vs. GG: OR = 2.16, p  = 0.035); dominant model (AG + AA vs. GG: OR = 2.26, p  < 0.05); overdominant model (AG vs. GG + AA: OR = 2.08, p  < 0.05); and allelic model (A vs. G: OR = 2.15, p  < 0.05). However, an insignificant association of breast cancer was found in both additive model 2 (AA vs. GG: OR = 2.91, p  > 0.05) and the recessive model (AA vs. GG + AG: OR = 2.52, p  > 0.05). Under the analysis of the probability of false positive reports, no significant values were found in different models when the OR was 1.5, and the prior probability was 0.25.
Conclusions: A significant relationship was found between the IL-6 rs1800797 genetic variant and the risk of breast cancer. However, the findings of the study should be further investigated with a larger sample size to validate the correlation.
Competing Interests: Dr. Mohammad Safiqul  Islam, a coauthor of this article, is a member of the Editorial Board of Health Science Reports. However, to minimize bias, he was excluded from any editorial decision‐making related to the acceptance of this article for publication. The remaining authors declare no conflict of interest.
(© 2024 The Authors. Health Science Reports published by Wiley Periodicals LLC.)
Databáze: MEDLINE
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