Combination of 5% cysteamine and 4% nicotinamide in melasma: Efficacy, tolerability, and safety.
Autor: | Crocco EI; Rua Barata Ribeiro, São Paulo, Brazil., Torloni L; Rua Barata Ribeiro, São Paulo, Brazil., Fernandes PB; Rua Barata Ribeiro, São Paulo, Brazil., de Campos MEBB; Rua Barata Ribeiro, São Paulo, Brazil., Gonzaga M; Rua Barata Ribeiro, São Paulo, Brazil., Silva FC; Rua Barata Ribeiro, São Paulo, Brazil., Nasario JPS; Rua Barata Ribeiro, São Paulo, Brazil., Guerra LO; Rua Barata Ribeiro, São Paulo, Brazil., Csipak AR; Rua Barata Ribeiro, São Paulo, Brazil., Castilho VC; Rua Barata Ribeiro, São Paulo, Brazil. |
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Jazyk: | angličtina |
Zdroj: | Journal of cosmetic dermatology [J Cosmet Dermatol] 2024 May; Vol. 23 (5), pp. 1703-1712. Date of Electronic Publication: 2024 Feb 07. |
DOI: | 10.1111/jocd.16183 |
Abstrakt: | Background: Melasma is a chronic dermatosis that impacts the patient's quality of life and can present considerable challenges in terms of effective treatment. Objective: To evaluate the effectiveness, tolerability, and safety of 5% cysteamine combined with 4% nicotinamide in female subjects with melasma. Methods: This single-center, single-arm, prospective, open-label study evaluated patients with melasma using a combination cream of 5% cysteamine and 4% nicotinamide in a progressive regimen (60 min in the first month, 120 min in the second month, and 180 min in the third month). Results: Overall, 35 treated subjects exhibited reduced modified Melasma Area and Severity Index (mMASI) (p < 0.001) and decreased MelasQoL scores (p < 0.001), accompanied by improved brightness, luminosity, homogeneity, and spot intensity (p < 0.001). Photographic and colorimetric analysis revealed smaller spots and improved homogeneity. Limitations: Adherence to progressive daily treatment could not be evaluated long-term. Conclusion: A combination cream comprising 5% cysteamine and 4% nicotinamide was effective, tolerable, and safe for treating melasma. (© 2024 Libbs Farmaceutica Ltda. Journal of Cosmetic Dermatology published by Wiley Periodicals LLC.) |
Databáze: | MEDLINE |
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