The impact of cage dividers on mouse aggression, dominance and hormone levels.

Autor: Streiff C; Animal Welfare Division, Vetsuisse Faculty, University of Bern, Bern, Switzerland., Herrera A; Animal Welfare Division, Vetsuisse Faculty, University of Bern, Bern, Switzerland., Voelkl B; Animal Welfare Division, Vetsuisse Faculty, University of Bern, Bern, Switzerland., Palme R; Unit of Physiology, Pathophysiology, and Experimental Endocrinology, Department of Biomedical Sciences, University of Veterinary Medicine, Vienna, Austria., Würbel H; Animal Welfare Division, Vetsuisse Faculty, University of Bern, Bern, Switzerland., Novak J; Animal Welfare Division, Vetsuisse Faculty, University of Bern, Bern, Switzerland.
Jazyk: angličtina
Zdroj: PloS one [PLoS One] 2024 Feb 07; Vol. 19 (2), pp. e0297358. Date of Electronic Publication: 2024 Feb 07 (Print Publication: 2024).
DOI: 10.1371/journal.pone.0297358
Abstrakt: Home cage aggression in group-housed male mice is a major welfare concern and may compromise animal research. Conventional cages prevent flight or retreat from sight, increasing the risk that agonistic encounters will result in injury. Moreover, depending on social rank, mice vary in their phenotype, and these effects seem highly variable and dependent on the social context. Interventions that reduce aggression, therefore, may reduce not only injuries and stress, but also variability between cage mates. Here we housed male mice (Balb/c and SWISS, group sizes of three and five) with or without partial cage dividers for two months. Mice were inspected for wounding weekly and home cages were recorded during housing and after 6h isolation housing, to assess aggression and assign individual social ranks. Fecal boli and fur were collected to quantify steroid levels. We found no evidence that the provision of cage dividers improves the welfare of group housed male mice; The prevalence of injuries and steroid levels was similar between the two housing conditions and aggression was reduced only in Balb/c strain. However, mice housed with cage dividers developed less despotic hierarchies and had more stable social ranks. We also found a relationship between hormone levels and social rank depending on housing type. Therefore, addition of cage dividers may play a role in stabilizing social ranks and modulating the activation of hypothalamic-pituitary-adrenal (HPA) and hypothalamic-pituitary-gonadal (HPG) axes, thus reducing phenotypic variability between mice of different ranks.
Competing Interests: The authors have declared that no competing interests exist.
(Copyright: © 2024 Streiff et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
Databáze: MEDLINE
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