Neuroprotective effect of ranolazine improves behavioral discrepancies in a rat model of scopolamine-induced dementia.

Autor:	Samir SM; Department of Medical Physiology, Faculty of Medicine, Mansoura University, Mansoura, Egypt., Hassan HM; Department of Human Anatomy and Embryology, Faculty of Medicine, Mansoura University, Mansoura, Egypt., Elmowafy R; Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Mansoura University, Mansoura, Egypt., ElNashar EM; Department of Anatomy, College of Medicine, King Khalid University, Abha, Saudi Arabia., Alghamdi MA; Department of Anatomy, College of Medicine, King Khalid University, Abha, Saudi Arabia.; Genomics and Personalized Medicine Unit, College of Medicine, King Khalid University, Abha, Saudi Arabia., AlSheikh MH; Department of Physiology, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia., Al-Zahrani NS; Department of Clinical Biochemistry, College of Medicine, King Khalid University, Abha, Saudi Arabia., Alasiri FM; Pharmacist in King Fahad Armed Forces Hospital Khamis Mushait, Khamis Mushait, Saudi Arabia., Elhadidy MG; Department of Medical Physiology, Faculty of Medicine, Mansoura University, Mansoura, Egypt.; Department of Medical Physiology, Faculty of Medicine, Al-Baha University, Al-Baha, Saudi Arabia.
Jazyk:	angličtina
Zdroj:	Frontiers in neuroscience [Front Neurosci] 2024 Jan 12; Vol. 17, pp. 1267675. Date of Electronic Publication: 2024 Jan 12 (Print Publication: 2023).
DOI:	10.3389/fnins.2023.1267675
Abstrakt:	Background: Ranolazine (Rn), an antianginal agent, acts in the central nervous system and has been used as a potential treatment agent for pain and epileptic disorders. Alzheimer's disease (AD) is one of the most prevalent neurodegenerative diseases and the leading factor in dementia in the elderly. Aim: We examined the impact of Rn on scopolamine (Sco)-induced dementia in rats. Methods: Thirty-two albino male rats were divided into four groups: control, Rn, Sco, and Rn + Sco. Results: A significant decrease in the escape latency in the Morris water maze test after pre-treatment with Rn explained better learning and memory in rats. Additionally, Rn significantly upregulated the activities of the antioxidant enzymes in the treated group compared to the Sco group but substantially reduced acetylcholinesterase activity levels in the hippocampus. Moreover, Rn dramatically reduced interleukin-1 β (IL-1β) and IL-6 and upregulated the gene expression of brain-derived neurotrophic factor (BDNF). Furthermore, in the Sco group, the hippocampal tissue's immunohistochemical reaction of Tau and glial factor activating protein (GFAP) was significantly increased in addition to the upregulation of the Caspase-3 gene expression, which was markedly improved by pre-treatment with Rn. The majority of pyramidal neurons had large vesicular nuclei with prominent nucleoli and appeared to be more or less normal, reflecting the all-beneficial effects of Rn when the hippocampal tissue was examined under a microscope. Conclusion: Our findings indicated that Rn, through its antioxidative, anti-inflammatory, and anti-apoptotic effects, as well as the control of the expression of GFAP, BDNF, and Tau proteins, has a novel neuroprotective impact against scopolamine-induced dementia in rats. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2024 Hassan, Elmowafy, ElNashar, Alghamdi, AlSheikh, Al-Zahrani, Alasiri and Elhadidy.)
Databáze:	MEDLINE
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