The impact of regional origin on the incidence of gestational diabetes mellitus in a multiethnic European cohort.

Autor:	Kotzaeridi G; Department of Obstetrics and Gynaecology, Medical University of Vienna, Vienna, Austria., Monod C; Department of Obstetrics and Gynaecology, University Hospital Basel, Basel, Switzerland., Linder T; Department of Obstetrics and Gynaecology, Medical University of Vienna, Vienna, Austria., Eppel D; Department of Obstetrics and Gynaecology, Medical University of Vienna, Vienna, Austria., Seidel V; Clinic of Obstetrics, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany., Feichtinger M; Wunschbaby Institute Feichtinger, Vienna, Austria., Mosimann B; Department of Obstetrics and Gynaecology, University Hospital Basel, Basel, Switzerland., Filippi V; Department of Obstetrics and Gynaecology, University Hospital Basel, Basel, Switzerland., Wegener S; Clinic of Obstetrics, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany., Henrich W; Clinic of Obstetrics, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany., Tura A; Metabolic Unit, CNR Institute of Neuroscience, Padova, Italy., Göbl CS; Department of Obstetrics and Gynaecology, Medical University of Vienna, Vienna, Austria.; Department of Obstetrics and Gynaecology, Division of Obstetrics, Medical University of Graz, Graz, Austria.
Jazyk:	angličtina
Zdroj:	Frontiers in public health [Front Public Health] 2024 Jan 19; Vol. 11, pp. 1286056. Date of Electronic Publication: 2024 Jan 19 (Print Publication: 2023).
DOI:	10.3389/fpubh.2023.1286056
Abstrakt:	Introduction: Women with migration background present specific challenges related to risk stratification and care of gestational diabetes mellitus (GDM). Therefore, this study aims to investigate the role of ethnic origin on the risk of developing GDM in a multiethnic European cohort. Methods: Pregnant women were included at a median gestational age of 12.9 weeks and assigned to the geographical regions of origin: Caucasian Europe ( n  = 731), Middle East and North Africa countries (MENA, n  = 195), Asia ( n  = 127) and Sub-Saharan Africa (SSA, n  = 48). At the time of recruitment maternal characteristics, glucometabolic parameters and dietary habits were assessed. An oral glucose tolerance test was performed in mid-gestation for GDM diagnosis. Results: Mothers with Caucasian ancestry were older and had higher blood pressure and an adverse lipoprotein profile as compared to non-Caucasian mothers, whereas non-Caucasian women (especially those from MENA countries) had a higher BMI and were more insulin resistant. Moreover, we found distinct dietary habits. Non-Caucasian mothers, especially those from MENA and Asian countries, had increased incidence of GDM as compared to the Caucasian population (OR 1.87, 95%CI 1.40 to 2.52, p  < 0.001). Early gestational fasting glucose and insulin sensitivity were consistent risk factors across different ethnic populations, however, pregestational BMI was of particular importance in Asian mothers. Discussion: Prevalence of GDM was higher among women from MENA and Asian countries, who already showed adverse glucometabolic profiles at early gestation. Fasting glucose and early gestational insulin resistance (as well as higher BMI in women from Asia) were identified as important risk factors in Caucasian and non-Caucasian patients. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision. (Copyright © 2024 Kotzaeridi, Monod, Linder, Eppel, Seidel, Feichtinger, Mosimann, Filippi, Wegener, Henrich, Tura and Göbl.)
Databáze:	MEDLINE
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