Postoperative small bowel Crohn's disease: how to diagnose, manage and treat.
| Autor: | Ip CL; National Hospital for Neurology and Neurosurgery, University College London Hospitals NHS Foundation Trust, London.; The Centre for Liver and Digestive Disorders, Royal Infirmary of Edinburgh, Edinburgh UK., Boyapati R; Department of Gastroenterology, Monash Medical Centre, Melbourne, Australia., Kalla R; The Centre for Liver and Digestive Disorders, Royal Infirmary of Edinburgh, Edinburgh UK.; Gut Research Unit, Institute of Regeneration and Repair, University of Edinburgh, Edinburgh, UK. |
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| Jazyk: | angličtina |
| Zdroj: | Current opinion in gastroenterology [Curr Opin Gastroenterol] 2024 May 01; Vol. 40 (3), pp. 209-216. Date of Electronic Publication: 2024 Jan 31. |
| DOI: | 10.1097/MOG.0000000000001007 |
| Abstrakt: | Purpose of Review: Crohn's disease is a relapsing inflammatory condition and disease recurrence after surgery is common. Significant variation in clinical practice remains despite progress in management of postoperative Crohn's disease. In this review, we summarise current management strategies and guidelines, unmet needs, and research progress in this field. Recent Findings: There has been real progress in risk stratifying individuals' postsurgery and tailoring therapies based on their risk; this has been incorporated into current management guidelines in the USA, UK, and Europe. Furthermore, novel noninvasive monitoring tools such as intestinal ultrasound have shown high sensitivity and specificity at detecting disease recurrence and are an attractive point-of-care test. Recent studies are also investigating multiomic biomarkers to prognosticate postoperative Crohn's disease. However, given the heterogeneity within this condition, large multicentre clinical validation across all age groups is needed for clinical translation in the future. Summary: Ongoing progress in research and the development of novel prognostic and noninvasive disease monitoring tools offers hope for personalised therapy tailored to individual recurrence risk in postoperative Crohn's disease. (Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.) |
| Databáze: | MEDLINE |
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