A review on hyphenation of droplet microfluidics to separation techniques: From instrumental conception to analytical applications for limited sample volumes.

Autor: Zohouri D; Université Paris-Saclay, CNRS, Institut Galien Paris-Saclay, 91400, Orsay, France., Lienard-Mayor T; Université Paris-Saclay, CNRS, Institut Galien Paris-Saclay, 91400, Orsay, France., Obeid S; Université Paris-Saclay, CNRS, Institut Galien Paris-Saclay, 91400, Orsay, France., Taverna M; Université Paris-Saclay, CNRS, Institut Galien Paris-Saclay, 91400, Orsay, France., Mai TD; Université Paris-Saclay, CNRS, Institut Galien Paris-Saclay, 91400, Orsay, France. Electronic address: thanh-duc.mai@universite-paris-saclay.fr.
Jazyk: angličtina
Zdroj: Analytica chimica acta [Anal Chim Acta] 2024 Feb 22; Vol. 1291, pp. 342090. Date of Electronic Publication: 2023 Dec 02.
DOI: 10.1016/j.aca.2023.342090
Abstrakt: In this study, we review various strategies to couple sample processing in microfluidic droplets with different separation techniques, including liquid chromatography, mass spectrometry, and capillary electrophoresis. Separation techniques interfaced with droplet microfluidics represent an emerging trend in analytical chemistry, in which micro to femtoliter droplets serve as microreactors, a bridge between analytical modules, as well as carriers of target analytes between sample treatment and separation/detection steps. This allows to overcome the hurdles encountered in separation science, notably the low degree of module integration, working volume incompatibility, and cross contamination between different operational stages. For this droplet-separation interfacing purpose, this review covers different instrumental designs from all works on this topic up to May 2023, together with our viewpoints on respective advantages and considerations. Demonstration and performance of droplet-interfaced separation strategies for limited sample volumes are also discussed.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2023 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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