New cassane-type alkaloids and diterpenoids from the pericarps of Caesalpinia bonduc.

Autor: Yan SJ; School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, No. 260 Baichuan Street, Hangzhou 311402, People's Republic of China., Huang SY; School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, No. 260 Baichuan Street, Hangzhou 311402, People's Republic of China., Xing JS; School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, No. 260 Baichuan Street, Hangzhou 311402, People's Republic of China., Cai YR; School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, No. 260 Baichuan Street, Hangzhou 311402, People's Republic of China., Ruan YP; School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, No. 260 Baichuan Street, Hangzhou 311402, People's Republic of China. Electronic address: 372739049@qq.com., Zhang PP; School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, No. 260 Baichuan Street, Hangzhou 311402, People's Republic of China. Electronic address: zhangpanpan16@126.com.
Jazyk: angličtina
Zdroj: Fitoterapia [Fitoterapia] 2024 Mar; Vol. 173, pp. 105834. Date of Electronic Publication: 2024 Jan 26.
DOI: 10.1016/j.fitote.2024.105834
Abstrakt: The phytochemical investigation of the pericarps of Caesalpinia bonduc led to the isolation and identification of five new cassane-type alkaloids: caesalminines C - G (1-5) and six new diterpenoids: caesalbonducin K - P (6-11), along with seven known compounds (12-18). Compounds 1-5 were identified as a group of rare alkaloids possessing a tetracyclic cassane-type diterpenoid skeleton with a lactam D-ring instead of a typical furan or lactone moiety. The structures of 1-11 were elucidated on the basis of 1D and 2D NMR including HSQC, HMBC, COSY and NOESY, and other spectroscopic analyses. The cytotoxic activities of the isolated compounds were evaluated in the A431, A549 and U87MG cancer cell lines.
Competing Interests: Declaration of competing interest The authors of the present manuscript have declared that no competing interests exist.
(Copyright © 2024. Published by Elsevier B.V.)
Databáze: MEDLINE
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