| Autor: |
Katunina EA; Federal Center of Brain and Neurotechnologies, Moscow, Russia.; Pirogov Russian National Research Medical University Ministry of Health of Russia, Moscow, Russia., Semenova AM; Federal Center of Brain and Neurotechnologies, Moscow, Russia., Katunin DA; Federal Center of Brain and Neurotechnologies, Moscow, Russia. |
| Jazyk: |
ruština |
| Zdroj: |
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova [Zh Nevrol Psikhiatr Im S S Korsakova] 2024; Vol. 124 (1), pp. 38-44. |
| DOI: |
10.17116/jnevro202412401138 |
| Abstrakt: |
Intestinal dysfunction and microbiome changes are actively discussed in the modern literature as the most important link in the development of neurodegenerative changes in Parkinson's disease. The article discusses the pathogenetic chain «microbiome- intestine-brain», as well as factors that affect the development of intestinal dysbiosis. A promising direction for influencing microflora and inflammatory changes in the intestine is the use of polyphenols, primarily curcumin. The review of experimental, laboratory, clinical research proving the pleiotropic effect of curcumin, including its antioxidant, anti-inflammatory, neuroprotective effects, realized both through peripheral and central mechanisms is presented. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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