The brainstem's red nucleus was evolutionarily upgraded to support goal-directed action.

Autor: Krimmel SR; Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, USA., Laumann TO; Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, USA., Chauvin RJ; Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, USA., Hershey T; Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, USA.; Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, USA.; Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri, USA.; Department of Psychological & Brain Sciences, Washington University, St. Louis, Missouri, USA., Roland JL; Department of Neurosurgery, Washington University School of Medicine, St. Louis, Missouri, USA., Shimony JS; Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri, USA., Willie JT; Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, USA.; Department of Psychiatry, Weill Cornell Medicine, New York, New York, USA.; Department of Neuroscience, Washington University School of Medicine, St. Louis, Missouri., Norris SA; Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, USA.; Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri, USA., Marek S; Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri, USA., Van AN; Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, USA.; Department of Biomedical Engineering, Washington University, St. Louis, Missouri., Monk J; Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, USA., Scheidter KM; Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, USA., Whiting F; Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, USA., Ramirez-Perez N; Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, USA.; Department of Neurosurgery, Washington University School of Medicine, St. Louis, Missouri, USA., Metoki A; Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, USA., Wang A; Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri, USA.; Division of Computation and Data Science, Washington University, St. Louis, Missouri, USA., Kay BP; Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, USA., Nahman-Averbuch H; Washington University Pain Center, Department of Anesthesiology, Washington University School of Medicine, St. Louis, Missouri, USA., Fair DA; Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota, USA.; Masonic Institute for the Developing Brain, University of Minnesota, Minneapolis, Minnesota, USA.; Institute of Child Development, University of Minnesota, Minneapolis, Minnesota, USA., Lynch CJ; Department of Psychiatry, Weill Cornell Medicine, New York, New York, USA., Raichle ME; Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, USA.; Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri, USA.; Department of Psychological & Brain Sciences, Washington University, St. Louis, Missouri, USA.; Department of Neuroscience, Washington University School of Medicine, St. Louis, Missouri.; Department of Biomedical Engineering, Washington University, St. Louis, Missouri., Gordon EM; Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri, USA., Dosenbach NUF; Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, USA.; Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri, USA.; Department of Psychological & Brain Sciences, Washington University, St. Louis, Missouri, USA.; Department of Biomedical Engineering, Washington University, St. Louis, Missouri.; Program in Occupational Therapy, Washington University, St. Louis, Missouri, USA.; Department of Pediatrics, Washington University School of Medicine, St. Louis, Missouri, USA.
Jazyk: angličtina
Zdroj: BioRxiv : the preprint server for biology [bioRxiv] 2024 Jan 01. Date of Electronic Publication: 2024 Jan 01.
DOI: 10.1101/2023.12.30.573730
Abstrakt: The red nucleus is a large brainstem structure that coordinates limb movement for locomotion in quadrupedal animals (Basile et al., 2021). The humans red nucleus has a different pattern of anatomical connectivity compared to quadrupeds, suggesting a unique purpose (Hatschek, 1907). Previously the function of the human red nucleus remained unclear at least partly due to methodological limitations with brainstem functional neuroimaging (Sclocco et al., 2018). Here, we used our most advanced resting-state functional connectivity (RSFC) based precision functional mapping (PFM) in highly sampled individuals (n = 5) and large group-averaged datasets (combined N ~ 45,000), to precisely examine red nucleus functional connectivity. Notably, red nucleus functional connectivity to motor-effector networks (somatomotor hand, foot, and mouth) was minimal. Instead, red nucleus functional connectivity along the central sulcus was specific to regions of the recently discovered somato-cognitive action network (SCAN; (Gordon et al., 2023)). Outside of primary motor cortex, red nucleus connectivity was strongest to the cingulo-opercular (CON) and salience networks, involved in action/cognitive control (Dosenbach et al., 2007; Newbold et al., 2021) and reward/motivated behavior (Seeley, 2019), respectively. Functional connectivity to these two networks was organized into discrete dorsal-medial and ventral-lateral zones. Red nucleus functional connectivity to the thalamus recapitulated known structural connectivity of the dento-rubral thalamic tract (DRTT) and could prove clinically useful in functionally targeting the ventral intermediate (VIM) nucleus. In total, our results indicate that far from being a 'motor' structure, the red nucleus is better understood as a brainstem nucleus for implementing goal-directed behavior, integrating behavioral valence and action plans.
Databáze: MEDLINE