The lateral habenula integrates age and experience to promote social transitions in developing rats.

Autor:	Cobb-Lewis D; Kennedy Krieger Institute, Baltimore MD USA 21205.; Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore MD USA 21205., George A; Kennedy Krieger Institute, Baltimore MD USA 21205., Hu S; Kennedy Krieger Institute, Baltimore MD USA 21205., Packard K; Kennedy Krieger Institute, Baltimore MD USA 21205., Song M; Kennedy Krieger Institute, Baltimore MD USA 21205.; Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore MD USA 21205., Nguyen-Lopez O; Kennedy Krieger Institute, Baltimore MD USA 21205.; Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore MD USA 21205., Tesone E; Kennedy Krieger Institute, Baltimore MD USA 21205.; Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore MD USA 21205., Rowden J; Kennedy Krieger Institute, Baltimore MD USA 21205.; Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore MD USA 21205., Wang J; Kennedy Krieger Institute, Baltimore MD USA 21205., Opendak M; Kennedy Krieger Institute, Baltimore MD USA 21205.; Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore MD USA 21205.
Jazyk:	angličtina
Zdroj:	BioRxiv : the preprint server for biology [bioRxiv] 2024 Jan 14. Date of Electronic Publication: 2024 Jan 14.
DOI:	10.1101/2024.01.12.575446
Abstrakt:	Social behavior deficits are an early-emerging marker of psychopathology and are linked with early caregiving quality. However, the infant neural substrates linking early care to social development are poorly understood. Here, we focused on the infant lateral habenula (LHb), a highly-conserved brain region at the nexus between forebrain and monoaminergic circuits. Despite its consistent links to adult psychopathology, this brain region has been understudied in development when the brain is most vulnerable to environmental impacts. In a task combining social and threat cues, suppressing LHb principal neurons had opposing effects in infants versus juveniles, suggesting the LHb promotes a developmental switch in social approach behavior under threat. We observed that early caregiving adversity (ECA) disrupts typical growth curves of LHb baseline structure and function, including volume, firing patterns, neuromodulatory receptor expression, and functional connectivity with cortical regions. Further, we observed that suppressing cortical projections to the LHb rescued social approach deficits following ECA, identifying this microcircuit as a substrate for disrupted social behavior. Together, these results identify immediate biomarkers of ECA in the LHb and highlight this region as a site of early social processing and behavior control. Competing Interests: Declaration of Interests The authors declare no competing interests.
Databáze:	MEDLINE
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