In-vitro and In Silico Assessment of Anti-inflammation Properties of Saponarin Extracted from Hordeum Vulgare.

Autor:	Boyina R; Department of Pharmacology, QIS College of Pharmacy, Vengamukkapalem, Ongole, Andhra Pradesh, India., Kosanam S; Department of Pharmacy Practice, Sandip Institute of Pharmaceutical Sciences, Nashik, Maharashtra, India., Bhimana S; Department of Pharmaceutical Biotechnology, QIS College of Pharmacy, Vengamukkapalem, Ongole, Andhra Pradesh, India., Gudimitla RB; Department of Pharmaceutical Analysis, QIS College of Pharmacy, Vengamukkapalem, Ongole, Andhra Pradesh, India., Duraiswamy D; Vengamukkapalem, Ongole, Andhra Pradesh.
Jazyk:	angličtina
Zdroj:	Anti-inflammatory & anti-allergy agents in medicinal chemistry [Antiinflamm Antiallergy Agents Med Chem] 2024; Vol. 23 (1), pp. 14-20.
DOI:	10.2174/0118715230284334240101100450
Abstrakt:	Background: Hordeum vulgare, commonly known as Barley grass, is a historically significant cultivated plant with profound implications for societies, agricultural sciences, and human nutrition. It has been valued for both sustenance and its potential medicinal properties. Objectives: This study aims to comprehensively investigate the medicinal properties of Hordeum vulgare, focusing on its potential therapeutic benefits and anti-inflammatory properties. Additionally, we seek to quantify and compare the phytochemical content of two distinct extracts: Barley Grass Hexane Extract (BGHE) and Barley grass aqueous extract (BGAQ). Methods: We quantified the phytochemical contents of BGHE and BGAQ and evaluated their anti-inflammatory effects using UV spectroscopy at 560 nm, coupled with the RBC membrane stabilization technique. Subsequently, we conducted in silico studies to assess the in vitro anti-inflammatory potential of Barley grass leaf extracts. Results: Both BGHE and BGAQ demonstrated significant inhibitory effects on inflammation compared to the control group. However, BGHE exhibited superior anti-inflammatory efficacy when compared to BGAQ, suggesting its role as a potential anti-inflammatory agent. In silico studies further supported the anti-inflammatory potential of Barley grass leaf extracts. Conclusion: Hordeum vulgare, or Barley grass, offers a wealth of health benefits, including anti-inflammatory, anti-diabetic, anti-cancer, antioxidant, anti-acne, and anti-depressant properties. These properties contribute to improved immunity, reduced cardiovascular disorders, and alleviation of fatigue. The distinct extracts, BGHE and BGAQ, both exhibit promising anti-inflammatory capabilities, but BGHE shows better anti-inflammatory activity. This research sheds light on the therapeutic potential of Barley grass, making it a valuable candidate for further exploration in the field of natural medicine. (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.)
Databáze:	MEDLINE
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