National Multicenter Study on the Comparison of Robotic and Open Thymectomy for Thymic Neoplasms in Myasthenic Patients: Surgical, Neurological and Oncological Outcomes.

Autor: Sicolo E; Minimally Invasive and Robotic Thoracic Surgery-Surgical, Medical, Molecular and Critical Care Pathology Department, University Hospital of Pisa, 56124 Pisa, Italy., Zirafa CC; Minimally Invasive and Robotic Thoracic Surgery-Surgical, Medical, Molecular and Critical Care Pathology Department, University Hospital of Pisa, 56124 Pisa, Italy., Romano G; Minimally Invasive and Robotic Thoracic Surgery-Surgical, Medical, Molecular and Critical Care Pathology Department, University Hospital of Pisa, 56124 Pisa, Italy., Brandolini J; Department of Thoracic Surgery, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, Italy., De Palma A; Unit of Thoracic Surgery, Department of Precision and Regenerative Medicine and Ionian Area, University of Bari 'Aldo Moro', 70121 Bari, Italy., Bongiolatti S; Thoracic Surgery Unit, Department of Experimental and Clinical Medicine, Careggi University Hospital, 50134 Florence, Italy., Gallina FT; Thoracic Surgery Unit IRCCS Regina Elena National Cancer Center, 00144 Rome, Italy., Ricciardi S; Unit of Thoracic Surgery, Azienda Ospedaliera San Camillo Forlanini, 00152 Rome, Italy., Maestri M; Neurology Unit, Department of Clinical and Experimental Medicine, University Hospital of Pisa, 56124 Pisa, Italy., Guida M; Neurology Unit, Department of Clinical and Experimental Medicine, University Hospital of Pisa, 56124 Pisa, Italy., Morganti R; Section of Statistics, University Hospital of Pisa, 56124 Pisa, Italy., Carleo G; Unit of Thoracic Surgery, Department of Precision and Regenerative Medicine and Ionian Area, University of Bari 'Aldo Moro', 70121 Bari, Italy., Mugnaini G; Thoracic Surgery Unit, Department of Experimental and Clinical Medicine, Careggi University Hospital, 50134 Florence, Italy., Tajè R; Thoracic Surgery Unit IRCCS Regina Elena National Cancer Center, 00144 Rome, Italy., Calabró F; Minimally Invasive and Robotic Thoracic Surgery-Surgical, Medical, Molecular and Critical Care Pathology Department, University Hospital of Pisa, 56124 Pisa, Italy., Lenzini A; Minimally Invasive and Robotic Thoracic Surgery-Surgical, Medical, Molecular and Critical Care Pathology Department, University Hospital of Pisa, 56124 Pisa, Italy., Davini F; Minimally Invasive and Robotic Thoracic Surgery-Surgical, Medical, Molecular and Critical Care Pathology Department, University Hospital of Pisa, 56124 Pisa, Italy., Cardillo G; Unit of Thoracic Surgery, Azienda Ospedaliera San Camillo Forlanini, 00152 Rome, Italy., Facciolo F; Thoracic Surgery Unit IRCCS Regina Elena National Cancer Center, 00144 Rome, Italy., Voltolini L; Thoracic Surgery Unit, Department of Experimental and Clinical Medicine, Careggi University Hospital, 50134 Florence, Italy., Marulli G; Unit of Thoracic Surgery, Department of Precision and Regenerative Medicine and Ionian Area, University of Bari 'Aldo Moro', 70121 Bari, Italy., Solli P; Department of Thoracic Surgery, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, Italy., Melfi F; Minimally Invasive and Robotic Thoracic Surgery-Surgical, Medical, Molecular and Critical Care Pathology Department, University Hospital of Pisa, 56124 Pisa, Italy.
Jazyk: angličtina
Zdroj: Cancers [Cancers (Basel)] 2024 Jan 18; Vol. 16 (2). Date of Electronic Publication: 2024 Jan 18.
DOI: 10.3390/cancers16020406
Abstrakt: Thymectomy is the gold standard in the treatment of thymic neoplasm and plays a key role in the therapeutic path of myasthenia gravis. For years, sternotomy has been the traditional approach for removing anterior mediastinal lesions, although the robotic thymectomy is now widely performed. The literature is still lacking in papers comparing the two approaches and evaluating long-term oncological and neurological outcomes. This study aims to analyze the postoperative results of open and robotic thymectomy for thymic neoplasms in myasthenic patients. Surgical, oncological and neurological data of myasthenic patients affected by thymic neoplasms and surgically treated with extended thymectomy, both with the open and the robotic approach, in six Italian Thoracic Centers between 2011 and 2021 were evaluated. A total of 213 patients were enrolled in the study: 110 (51.6%) were treated with the open approach, and 103 (48.4%) were treated with robotic surgery. The open surgery, compared with the robotic, presented a shorter operating time ( p < 0.001), a higher number of postoperative complications ( p = 0.038) and longer postoperative hospitalization ( p = 0.006). No other differences were observed in terms of surgical, oncological or neurological outcomes. The robotic approach can be considered safe and feasible, comparable to the open technique, in terms of surgical, oncological and neurological outcomes.
Databáze: MEDLINE
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