Age-stratified Assessment of Brain Volumetric Segmentation on the Indian Population Using Quantitative Magnetic Resonance Imaging.

Autor: Syed Nasser N; Mahajan Imaging and Labs, New Delhi, India. nishasyed2096@gmail.com., Venugopal VK; CARPL.ai, New Delhi, India., Veenstra C; SyntheticMR AB, Linköping, Sweden., Johansson P; SyntheticMR AB, Linköping, Sweden., Rajan S; Mahajan Imaging and Labs, New Delhi, India., Mahajan K; Mahajan Imaging and Labs, New Delhi, India., Naik S; Batra Hospital & Medical Research Centre, New Delhi, India., Masand R; CHL Hospital, Indore, India., Yadav P; Dr. D. Y. Patil Medical College, Hospital and Research Centre, Pune, India., Khanduri S; Era's Lucknow Medical College and Hospital, Lucknow, India., Singhal S; Fortis Escorts Hospital, Jaipur, India., Bhargava R; Fortis Hospital, Mumbai, India., Kabra U; Getwell Polyclinic & Hospital, Jaipur, India., Gupta S; HealthCare Imaging Centre, Meerut, India., Saggar K; Dayanand Medical College & Hospital, Ludhiana, India., Varaprasad B; Kamineni Hospital, Hyderabad, India., Aggrawal K; Kriti Scanning Center, Prayagraj, India., Rao A; MA Advanced Diagnostic & Research Centre, Guntur, India., K S M; Metro Scans and Laboratory, Thiruvananthapuram, India., Dakhole A; MetroScan, Nagpur, India., Kelkar A; Omega PDSHospital, Pune, India., Benjamin G; Pushpagiri Medical College Hospital, Thiruvalla, India., Sodani V; Sampoorna Sodani Diagnostics, Indore, India., Goyal P; Vardhman Imaging, Jaipur, India., Mahajan H; Mahajan Imaging and Labs, New Delhi, India.
Jazyk: angličtina
Zdroj: Clinical neuroradiology [Clin Neuroradiol] 2024 Sep; Vol. 34 (3), pp. 541-551. Date of Electronic Publication: 2024 Jan 22.
DOI: 10.1007/s00062-023-01374-z
Abstrakt: Background and Purpose: Automated methods for quantifying brain tissue volumes have gained clinical interest for their objective assessment of neurological diseases. This study aimed to establish reference curves for brain volumes and fractions in the Indian population using Synthetic MRI (SyMRI), a quantitative imaging technique providing multiple contrast-weighted images through fast postprocessing.
Methods: The study included a cohort of 314 healthy individuals aged 15-65 years from multiple hospitals/centers across India. The SyMRI-quantified brain volumes and fractions, including brain parenchymal fraction (BPF), gray matter fraction (GMF), white matter fraction (WMF), and myelin.
Results: Normative age-stratified quantification curves were created based on the obtained data. The results showed significant differences in brain volumes between the sexes, but not after normalization by intracranial volume.
Conclusion: The findings provide normative data for the Indian population and can be used for comparative analysis of brain structure values. Furthermore, our data indicate that the use of fractions rather than absolute volumes in normative curves, such as BPF, GMF, and WMF, can mitigate sex and population differences as they account for individual differences in head size or brain volume.
(© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany.)
Databáze: MEDLINE
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