Frequency of potentially pathogenic bacterial and fungal isolates among 28,887 endometrial samples from mares, with an emphasis on multi-drug resistant bacteria in Germany (2018-2022).

Autor: Köhne M; Unit for Reproductive Medicine - Clinic for Horses, University of Veterinary Medicine, Foundation, Bünteweg 15, Hannover 30559, Germany. Electronic address: martin.koehne@tiho-hannover.de., Hegger A; Clinic for Horses Mühlen, Steinfeld, Oldenburg 49349, Germany., Tönissen A; Unit for Reproductive Medicine - Clinic for Horses, University of Veterinary Medicine, Foundation, Bünteweg 15, Hannover 30559, Germany., Heusinger A; Laboklin GmbH, Bad Kissingen 97688, Germany., Hader C; Laboklin GmbH, Bad Kissingen 97688, Germany., Görgens A; Clinic for Horses Mühlen, Steinfeld, Oldenburg 49349, Germany., Sieme H; Unit for Reproductive Medicine - Clinic for Horses, University of Veterinary Medicine, Foundation, Bünteweg 15, Hannover 30559, Germany.
Jazyk: angličtina
Zdroj: Journal of equine veterinary science [J Equine Vet Sci] 2024 Feb; Vol. 133, pp. 105008. Date of Electronic Publication: 2024 Jan 17.
DOI: 10.1016/j.jevs.2024.105008
Abstrakt: Antimicrobial-resistant bacteria pose a serious threat to the wellbeing of animals and humans. In equine reproduction, endometritis caused by facultative microbial pathogens is a condition, which is usually treated with antibiotics. Data from Germany on prevalence of facultative pathogenic microorganisms cultured in samples from the equine uterus and the frequency of multi-drug resistant (MDR) bacteria is lacking. The aim of the study was to provide representative numbers for both. Microbiological culture results (n = 28,887) of endometrial samples submitted to a large veterinary diagnostic laboratory from 2018-2022 were analyzed. An average of 25.9 % of the culture results showed growth of facultative pathogenic bacteria. The dominant isolated bacteria were β-hemolytic streptococci (79.7 %) followed by Escherichia (E.) coli variatio haemolytica (5.2 %). E. coli were cultured in 4.3 % of the samples and occurred more often than Klebsiella pneumoniae (3.9 %), Candida species (2.9 %), Pseudomonas aeruginosa (2.0 %), and Staphylococcus aureus (1.5 %). Antibiotic susceptibility testing revealed sensitivity of β-hemolytic streptococci towards penicillins in almost 100 % of the cultured samples (99.5 %). E. coli-isolates were sensitive to gentamicin in 96.2 % of the cases. The frequency of multidrug-resistant extended spectrum beta-lactamase (ESBL)-positive bacteria and methicillin-resistant Staphylococcus aureus (MRSA) was 3.1 % of all positive culture results. The number of ESBL-positive isolates (n = 159) and MRSA was stable from 2018-2022. In conclusion, the situation regarding occurrence of MDR bacteria in Germany is favorable, but should further be monitored.
Competing Interests: Declaration of competing interest The authors do not report any conflict of interest.
(Copyright © 2024 The Author(s). Published by Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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