Safety and Efficacy of Surgical and Percutaneous Cardiac Interventions for Adults With Down Syndrome.

Autor:	Roehl K; Department of Cardiovascular Diseases, Mayo Clinic, Scottsdale, AZ., Mead-Harvey C; Department of Quantitative Health Sciences, Mayo Clinic, Phoenix, Arizona., Connolly HM; Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN., Dearani JA; Department of Cardiovascular Surgery, Mayo Clinic, Rochester, MN., Schaap FS; Nurse Practitioner Fellow in Cardiology, Mayo Clinic School of Health Sciences, Mayo Clinic College of Medicine and Science, Phoenix, AZ.; University of Tennessee Medical Center, Knoxville, TN., Liljenstolpe SL; Nurse Practitioner Fellow in Cardiology, Mayo Clinic School of Health Sciences, Mayo Clinic College of Medicine and Science, Phoenix, AZ.; Cardiovascular Consultants Ltd, Phoenix, AZ., Osborn LB; Department of Nursing, Mayo Clinic, Scottsdale, AZ., Jain CC; Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN., Hagler DJ Sr; Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN.; Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN., Marcotte F; Department of Cardiovascular Diseases, Mayo Clinic, Scottsdale, AZ., Majdalany DS; Department of Cardiovascular Diseases, Mayo Clinic, Scottsdale, AZ.
Jazyk:	angličtina
Zdroj:	Mayo Clinic proceedings. Innovations, quality & outcomes [Mayo Clin Proc Innov Qual Outcomes] 2023 Dec 26; Vol. 8 (1), pp. 28-36. Date of Electronic Publication: 2023 Dec 26 (Print Publication: 2024).
DOI:	10.1016/j.mayocpiqo.2023.11.002
Abstrakt:	Objective: To assess risks and benefits of cardiac intervention in adults with Down syndrome (DS). Patients and Methods: A retrospective review was conducted using data from a study we published in 2010. Patients aged 18 years or older with DS who underwent cardiac operation or percutaneous intervention from February 2009 through April 2022 (new cohort) were compared with patients in the previous study (January 1969 through November 2007; remote cohort) at Mayo Clinic. Results: In total, 81 adults (43 men; 38 women) with DS underwent 89 cardiac interventions (84 surgical; 5 percutaneous) at a mean age of 33 years. Twenty-six patients presented with complete atrioventricular canal defect (17%) or tetralogy of Fallot (15%). The most common adult procedures were valve interventions: mitral (31%), tricuspid (15%), and pulmonary (12%). Of pulmonary valve interventions in the new cohort, 33% were performed percutaneously. The postoperative mortality rate was low (1% total). The mean time between last operation and death was 16 years. Conclusion: Adults with DS can undergo cardiac operation and percutaneous intervention with low morbidity and mortality risk and good long-term survival. Competing Interests: The authors report no competing interests. (© 2023 The Authors.)
Databáze:	MEDLINE
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