Heritability of cognitive and emotion processing during functional MRI in a twin sample.

Autor: Park HRP; Neuroscience Research Australia, Sydney, New South Wales, Australia.; School of Psychology, University of New South Wales, Sydney, New South Wales, Australia., Chilver MR; Neuroscience Research Australia, Sydney, New South Wales, Australia.; School of Psychology, University of New South Wales, Sydney, New South Wales, Australia., Quidé Y; Neuroscience Research Australia, Sydney, New South Wales, Australia.; School of Psychology, University of New South Wales, Sydney, New South Wales, Australia., Montalto A; Neuroscience Research Australia, Sydney, New South Wales, Australia.; School of Psychology, University of New South Wales, Sydney, New South Wales, Australia., Schofield PR; Neuroscience Research Australia, Sydney, New South Wales, Australia.; School of Biomedical Sciences, University of New South Wales, Sydney, New South Wales, Australia., Williams LM; Psychiatry and Behavioral Sciences, Stanford School of Medicine, Stanford University, California, USA., Gatt JM; Neuroscience Research Australia, Sydney, New South Wales, Australia.; School of Psychology, University of New South Wales, Sydney, New South Wales, Australia.
Jazyk: angličtina
Zdroj: Human brain mapping [Hum Brain Mapp] 2024 Jan; Vol. 45 (1), pp. e26557.
DOI: 10.1002/hbm.26557
Abstrakt: Despite compelling evidence that brain structure is heritable, the evidence for the heritability of task-evoked brain function is less robust. Findings from previous studies are inconsistent possibly reflecting small samples and methodological variations. In a large national twin sample, we systematically evaluated heritability of task-evoked brain activity derived from functional magnetic resonance imaging. We used established standardised tasks to engage brain regions involved in cognitive and emotional functions. Heritability was evaluated across a conscious and nonconscious Facial Expressions of Emotion Task (FEET), selective attention Oddball Task, N-back task of working memory maintenance, and a Go-NoGo cognitive control task in a sample of Australian adult twins (N ranged from 136 to 226 participants depending on the task and pairs). Two methods for quantifying associations of heritability and brain activity were utilised; a multivariate independent component analysis (ICA) approach and a univariate brain region-of-interest (ROI) approach. Using ICA, we observed that a significant proportion of task-evoked brain activity was heritable, with estimates ranging from 23% to 26% for activity elicited by nonconscious facial emotion stimuli, 27% to 34% for N-back working memory maintenance and sustained attention, and 32% to 33% for selective attention in the Oddball task. Using the ROI approach, we found that activity of regions specifically implicated in emotion processing and selective attention showed significant heritability for three ROIs, including estimates of 33%-34% for the left and right amygdala in the nonconscious processing of sad faces and 29% in the medial superior prefrontal cortex for the Oddball task. Although both approaches show similar levels of heritability for the Nonconscious Faces and Oddball tasks, ICA results displayed a more extensive network of heritable brain function, including additional regions beyond the ROI analysis. Furthermore, multivariate twin modelling of both ICA networks and ROI activation suggested a mix of common genetic and unique environmental factors that contribute to the associations between networks/regions. Together, the results indicate a complex relationship between genetic factors and environmental interactions that ultimately give rise to neural activation underlying cognition and emotion.
(© 2024 The Authors. Human Brain Mapping published by Wiley Periodicals LLC.)
Databáze: MEDLINE
Externí odkaz: