Risk-promoting effects of reward-paired cues in human sign- and goal-trackers.

Autor: Cherkasova MV; Department of Psychology, University of British Columbia, Vancouver, British Columbia, Canada; Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, British Columbia, Canada. Electronic address: mariya.cherkasova@mail.wvu.edu., Clark L; Department of Psychology, University of British Columbia, Vancouver, British Columbia, Canada; Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, British Columbia, Canada., Barton JJS; Department of Medicine, Division of Neurology, University of British Columbia, Vancouver, British Columbia, Canada; Department of Ophthalmology, University of British Columbia, Vancouver, British Columbia, Canada., Stoessl AJ; Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, British Columbia, Canada; Department of Medicine, Division of Neurology, University of British Columbia, Vancouver, British Columbia, Canada., Winstanley CA; Department of Psychology, University of British Columbia, Vancouver, British Columbia, Canada; Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, British Columbia, Canada. Electronic address: cwinstanley@psych.ubc.ca.
Jazyk: angličtina
Zdroj: Behavioural brain research [Behav Brain Res] 2024 Mar 12; Vol. 461, pp. 114865. Date of Electronic Publication: 2024 Jan 14.
DOI: 10.1016/j.bbr.2024.114865
Abstrakt: Animal research suggests trait-like individual variation in the degree of incentive salience attribution to reward-predictive cues, defined phenotypically as sign-tracking (high) and goal-tracking (low incentive salience attribution). While these phenotypes have been linked to addiction features in rodents, their translational validity is less clear. Here, we examined whether sign- and goal-tracking in healthy human volunteers modulates the effects of reward-paired cues on decision making. Sign-tracking was measured in a Pavlovian conditioning paradigm as the amount of eye gaze fixation on the reward-predictive cue versus the location of impending reward delivery. In Study 1 (Cherkasova et al., 2018), participants were randomly assigned to perform a binary choice task in which rewards were either accompanied (cued, n = 63) or unaccompanied (uncued, n = 68) by money images and casino jingles. In Study 2, participants (n = 58) performed cued and uncued versions of the task in a within-subjects design. Across both studies, cues promoted riskier choice. Sign-tracking was not associated with risky choice in either study. Goal-tracking rather than sign-tracking was significantly associated with greater risk-promoting effects of cues in Study 1 but not in Study 2, although the direction of findings was consistent across both studies. These findings are at odds with the notion of sign-trackers being preferentially susceptible to the influence of reward cues on behavior and point to the role of mechanisms besides incentive salience in mediating such influences.
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Databáze: MEDLINE
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