Deterministic reprogramming of neutrophils within tumors.

Autor: Ng MSF; Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Singapore., Kwok I; Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Singapore., Tan L; Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Singapore., Shi C; Shanghai Immune Therapy Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China., Cerezo-Wallis D; Area of Cell & Developmental Biology, Centro Nacional de Investigaciones Cardiovasculares Carlos III, Madrid, Spain.; Vascular Biology and Therapeutics Program and Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA., Tan Y; Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Singapore.; National Skin Centre, National Healthcare Group, Singapore., Leong K; Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Singapore., Calvo GF; Department of Mathematics & MOLAB-Mathematical Oncology Laboratory, University of Castilla-La Mancha, Ciudad Real, Spain., Yang K; Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Singapore., Zhang Y; Immunology Translational Research Program, Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; Immunology Program, Life Science Institute, National University of Singapore, Singapore., Jin J; Shanghai Immune Therapy Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China., Liong KH; Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Singapore., Wu D; Shanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine, Shanghai, China., He R; Shanghai Immune Therapy Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China., Liu D; Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Singapore., Teh YC; Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Singapore., Bleriot C; INSERM U1015, Institut Gustave Roussy, Villejuif, France.; CNRS UMR8253, Institut Necker des Enfants Malades, Paris, France., Caronni N; Genomics of the Innate Immune System Unit, San Raffaele-Telethon Institute for Gene Therapy (SR-Tiget), IRCCS San Raffaele Scientific Institute, Milan, Italy., Liu Z; Shanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine, Shanghai, China., Duan K; Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Singapore., Narang V; Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Singapore., Ballesteros I; Area of Cell & Developmental Biology, Centro Nacional de Investigaciones Cardiovasculares Carlos III, Madrid, Spain., Moalli F; Division of Immunology, Transplantation, and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy.; Experimental Imaging Centre, IRCCS San Raffaele Scientific Institute, Milan, Italy., Li M; Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Singapore., Chen J; Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Singapore., Liu Y; Department of Hepatobiliary Surgery, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Anhui, China., Liu L; Department of Hepatobiliary Surgery, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Anhui, China., Qi J; Department of Biliary and Pancreatic Surgery, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.; Shanghai Institute of Cancer Biology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China., Liu Y; Department of Biliary and Pancreatic Surgery, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.; Shanghai Institute of Cancer Biology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China., Jiang L; Department of General Surgery, Pancreatic Disease Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.; Research Institute of Pancreatic Diseases, Shanghai Key Laboratory of Translational Research for Pancreatic Neoplasms, Shanghai Jiao Tong University School of Medicine, Shanghai, China.; State Key Laboratory of Oncogenes and Related Genes, Institute of Translational Medicine, Shanghai Jiao Tong University, Shanghai, China., Shen B; Department of General Surgery, Pancreatic Disease Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.; Research Institute of Pancreatic Diseases, Shanghai Key Laboratory of Translational Research for Pancreatic Neoplasms, Shanghai Jiao Tong University School of Medicine, Shanghai, China.; State Key Laboratory of Oncogenes and Related Genes, Institute of Translational Medicine, Shanghai Jiao Tong University, Shanghai, China., Cheng H; State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China., Cheng T; State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China., Angeli V; Immunology Translational Research Program, Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; Immunology Program, Life Science Institute, National University of Singapore, Singapore., Sharma A; Harry Perkins Institute of Medical Research, QEII Medical Centre, Nedlands, Western Australia, Australia.; Curtin Medical School, Curtin University, Bentley, Western Australia, Australia.; Curtin Health Innovation Research Institute, Curtin University, Bentley, Western Australia, Australia., Loh YH; Institute of Molecular and Cell Biology (IMCB), A*STAR (Agency for Science, Technology and Research), Singapore., Tey HL; National Skin Centre, National Healthcare Group, Singapore.; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore.; Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Chong SZ; Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Singapore.; Department of Microbiology and Immunology, National University of Singapore, Singapore., Iannacone M; Division of Immunology, Transplantation, and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy.; Experimental Imaging Centre, IRCCS San Raffaele Scientific Institute, Milan, Italy.; Vita-Salute San Raffaele University, Milan, Italy., Ostuni R; Genomics of the Innate Immune System Unit, San Raffaele-Telethon Institute for Gene Therapy (SR-Tiget), IRCCS San Raffaele Scientific Institute, Milan, Italy.; Vita-Salute San Raffaele University, Milan, Italy., Hidalgo A; Area of Cell & Developmental Biology, Centro Nacional de Investigaciones Cardiovasculares Carlos III, Madrid, Spain.; Vascular Biology and Therapeutics Program and Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA., Ginhoux F; Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Singapore.; Shanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.; INSERM U1015, Institut Gustave Roussy, Villejuif, France.; Translational Immunology Institute, SingHealth Duke-NUS Academic Medical Centre, Singapore., Ng LG; Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Singapore.; Shanghai Immune Therapy Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.; Department of Microbiology and Immunology, National University of Singapore, Singapore.
Jazyk: angličtina
Zdroj: Science (New York, N.Y.) [Science] 2024 Jan 12; Vol. 383 (6679), pp. eadf6493. Date of Electronic Publication: 2024 Jan 12.
DOI: 10.1126/science.adf6493
Abstrakt: Neutrophils are increasingly recognized as key players in the tumor immune response and are associated with poor clinical outcomes. Despite recent advances characterizing the diversity of neutrophil states in cancer, common trajectories and mechanisms governing the ontogeny and relationship between these neutrophil states remain undefined. Here, we demonstrate that immature and mature neutrophils that enter tumors undergo irreversible epigenetic, transcriptional, and proteomic modifications to converge into a distinct, terminally differentiated dcTRAIL-R1 + state. Reprogrammed dcTRAIL-R1 + neutrophils predominantly localize to a glycolytic and hypoxic niche at the tumor core and exert pro-angiogenic function that favors tumor growth. We found similar trajectories in neutrophils across multiple tumor types and in humans, suggesting that targeting this program may provide a means of enhancing certain cancer immunotherapies.
Databáze: MEDLINE
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