100 ancient genomes show repeated population turnovers in Neolithic Denmark.

Autor: Allentoft ME; Lundbeck Foundation GeoGenetics Centre, Globe Institute, University of Copenhagen, Copenhagen, Denmark. morten.allentoft@curtin.edu.au.; Trace and Environmental DNA (TrEnD) Laboratory, School of Molecular and Life Sciences, Curtin University, Perth, Western Australia, Australia. morten.allentoft@curtin.edu.au., Sikora M; Lundbeck Foundation GeoGenetics Centre, Globe Institute, University of Copenhagen, Copenhagen, Denmark. martin.sikora@sund.ku.dk., Fischer A; Cluster of Excellence ROOTS, Kiel University, Kiel, Germany.; Sealand Archaeology, Kalundborg, Denmark., Sjögren KG; Department of Historical Studies, Gothenburg University, Göteborg, Sweden., Ingason A; Lundbeck Foundation GeoGenetics Centre, Globe Institute, University of Copenhagen, Copenhagen, Denmark.; Institute of Biological Psychiatry, Mental Health Center Sct. Hans, Copenhagen University Hospital, Copenhagen, Denmark., Macleod R; Lundbeck Foundation GeoGenetics Centre, Globe Institute, University of Copenhagen, Copenhagen, Denmark.; GeoGenetics Group, Department of Zoology, University of Cambridge, Cambridge, UK.; Research Department of Genetics, Evolution and Environment, University College London, London, UK., Rosengren A; Lundbeck Foundation GeoGenetics Centre, Globe Institute, University of Copenhagen, Copenhagen, Denmark.; Institute of Biological Psychiatry, Mental Health Center Sct. Hans, Copenhagen University Hospital, Copenhagen, Denmark., Schulz Paulsson B; Cluster of Excellence ROOTS, Kiel University, Kiel, Germany., Jørkov MLS; Laboratory of Biological Anthropology, University of Copenhagen, Copenhagen, Denmark., Novosolov M; Lundbeck Foundation GeoGenetics Centre, Globe Institute, University of Copenhagen, Copenhagen, Denmark., Stenderup J; Lundbeck Foundation GeoGenetics Centre, Globe Institute, University of Copenhagen, Copenhagen, Denmark., Price TD; Laboratory for Archaeological Chemistry, Department of Anthropology, University of Wisconsin-Madison, Madison, WI, USA., Fischer Mortensen M; The National Museum of Denmark, Copenhagen, Denmark., Nielsen AB; Department of Geology, Lund University, Lund, Sweden., Ulfeldt Hede M; Tårnby Gymnasium og HF, Kastrup, Denmark., Sørensen L; The National Museum of Denmark, Copenhagen, Denmark., Nielsen PO; The National Museum of Denmark, Copenhagen, Denmark., Rasmussen P; The National Museum of Denmark, Copenhagen, Denmark., Jensen TZT; Globe Institute, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Refoyo-Martínez A; Lundbeck Foundation GeoGenetics Centre, Globe Institute, University of Copenhagen, Copenhagen, Denmark., Irving-Pease EK; Lundbeck Foundation GeoGenetics Centre, Globe Institute, University of Copenhagen, Copenhagen, Denmark., Barrie W; GeoGenetics Group, Department of Zoology, University of Cambridge, Cambridge, UK.; Department of Genetics, University of Cambridge, Cambridge, UK., Pearson A; GeoGenetics Group, Department of Zoology, University of Cambridge, Cambridge, UK.; Department of Genetics, University of Cambridge, Cambridge, UK., Sousa da Mota B; Department of Computational Biology, University of Lausanne, Lausanne, Switzerland.; Swiss Institute of Bioinformatics, University of Lausanne, Lausanne, Switzerland., Demeter F; Lundbeck Foundation GeoGenetics Centre, Globe Institute, University of Copenhagen, Copenhagen, Denmark.; Eco-anthropologie (EA), Dpt ABBA, Muséum National d'Histoire Naturelle, CNRS, Université Paris Cité, Musée de l'Homme, Paris, France., Henriksen RA; Lundbeck Foundation GeoGenetics Centre, Globe Institute, University of Copenhagen, Copenhagen, Denmark., Vimala T; Lundbeck Foundation GeoGenetics Centre, Globe Institute, University of Copenhagen, Copenhagen, Denmark., McColl H; Lundbeck Foundation GeoGenetics Centre, Globe Institute, University of Copenhagen, Copenhagen, Denmark., Vaughn A; Center for Computational Biology, University of California, Berkeley, USA., Vinner L; Lundbeck Foundation GeoGenetics Centre, Globe Institute, University of Copenhagen, Copenhagen, Denmark., Renaud G; Department of Health Technology, Section of Bioinformatics, Technical University of Denmark, Kongens Lyngby, Denmark., Stern A; Center for Computational Biology, University of California, Berkeley, USA., Johannsen NN; Department of Archaeology and Heritage Studies, Aarhus University, Aarhus, Denmark., Ramsøe AD; Lundbeck Foundation GeoGenetics Centre, Globe Institute, University of Copenhagen, Copenhagen, Denmark., Schork AJ; Laboratory of Biological Anthropology, University of Copenhagen, Copenhagen, Denmark.; Neurogenomics Division, The Translational Genomics Research Institute (TGEN), Phoenix, AZ, USA., Ruter A; Lundbeck Foundation GeoGenetics Centre, Globe Institute, University of Copenhagen, Copenhagen, Denmark., Gotfredsen AB; Globe Institute, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Henning Nielsen B; Vesthimmerlands Museum, Aars, Denmark., Brinch Petersen E; The Saxo Institute, University of Copenhagen, Copenhagen, Denmark., Kannegaard E; Museum Østjylland, Randers, Denmark., Hansen J; Svendborg Museum, Svendborg, Denmark., Buck Pedersen K; Museum Sydøstdanmark, Vordingborg, Denmark., Pedersen L; HistorieUdvikler, Kalundborg, Denmark., Klassen L; Museum Østjylland, Randers, Denmark., Meldgaard M; Lundbeck Foundation GeoGenetics Centre, Globe Institute, University of Copenhagen, Copenhagen, Denmark.; Department of Health and Nature, University of Greenland, Nuuk, Greenland., Johansen M; The Viking Ship Museum, Roskilde, Denmark., Uldum OC; The Viking Ship Museum, Roskilde, Denmark., Lotz P; Museum Nordsjælland, Hillerød, Denmark.; Museum Vestsjælland, Holbæk, Denmark., Lysdahl P; Vendsyssel Historiske Museum, Hjørring, Denmark., Bangsgaard P; Globe Institute, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Petersen PV; The National Museum of Denmark, Copenhagen, Denmark., Maring R; Department of Archaeology and Heritage Studies, Aarhus University, Aarhus, Denmark.; Museum Østjylland, Randers, Denmark., Iversen R; The Saxo Institute, University of Copenhagen, Copenhagen, Denmark., Wåhlin S; Vendsyssel Historiske Museum, Hjørring, Denmark., Anker Sørensen S; Museum Nordsjælland, Hillerød, Denmark., Andersen SH; Moesgaard Museum, Højbjerg, Denmark., Jørgensen T; Museum Nordsjælland, Hillerød, Denmark., Lynnerup N; Laboratory of Biological Anthropology, Department of Forensic Medicine, University of Copenhagen, Copenhagen, Denmark., Lawson DJ; Institute of Statistical Sciences, School of Mathematics, University of Bristol, Bristol, UK., Rasmussen S; Novo Nordisk Foundation Centre for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen N, Denmark., Korneliussen TS; Lundbeck Foundation GeoGenetics Centre, Globe Institute, University of Copenhagen, Copenhagen, Denmark., Kjær KH; Lundbeck Foundation GeoGenetics Centre, Globe Institute, University of Copenhagen, Copenhagen, Denmark., Durbin R; Department of Genetics, University of Cambridge, Cambridge, UK.; Wellcome Sanger Institute, Wellcome Trust Genome Campus, Cambridge, UK., Nielsen R; Lundbeck Foundation GeoGenetics Centre, Globe Institute, University of Copenhagen, Copenhagen, Denmark.; Department of Integrative Biology and Statistics, UC Berkeley, Berkeley, CA, USA., Delaneau O; Department of Computational Biology, University of Lausanne, Lausanne, Switzerland.; Swiss Institute of Bioinformatics, University of Lausanne, Lausanne, Switzerland., Werge T; Lundbeck Foundation GeoGenetics Centre, Globe Institute, University of Copenhagen, Copenhagen, Denmark.; Institute of Biological Psychiatry, Mental Health Center Sct. Hans, Copenhagen University Hospital, Copenhagen, Denmark.; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark., Kristiansen K; Lundbeck Foundation GeoGenetics Centre, Globe Institute, University of Copenhagen, Copenhagen, Denmark.; Department of Historical Studies, Gothenburg University, Göteborg, Sweden., Willerslev E; Lundbeck Foundation GeoGenetics Centre, Globe Institute, University of Copenhagen, Copenhagen, Denmark. ew482@cam.ac.uk.; GeoGenetics Group, Department of Zoology, University of Cambridge, Cambridge, UK. ew482@cam.ac.uk.; MARUM Center for Marine Environmental Sciences and Faculty of Geosciences, University of Bremen, Bremen, Germany. ew482@cam.ac.uk.
Jazyk: angličtina
Zdroj: Nature [Nature] 2024 Jan; Vol. 625 (7994), pp. 329-337. Date of Electronic Publication: 2024 Jan 10.
DOI: 10.1038/s41586-023-06862-3
Abstrakt: Major migration events in Holocene Eurasia have been characterized genetically at broad regional scales 1-4 . However, insights into the population dynamics in the contact zones are hampered by a lack of ancient genomic data sampled at high spatiotemporal resolution 5-7 . Here, to address this, we analysed shotgun-sequenced genomes from 100 skeletons spanning 7,300 years of the Mesolithic period, Neolithic period and Early Bronze Age in Denmark and integrated these with proxies for diet ( 13 C and 15 N content), mobility ( 87 Sr/ 86 Sr ratio) and vegetation cover (pollen). We observe that Danish Mesolithic individuals of the Maglemose, Kongemose and Ertebølle cultures form a distinct genetic cluster related to other Western European hunter-gatherers. Despite shifts in material culture they displayed genetic homogeneity from around 10,500 to 5,900 calibrated years before present, when Neolithic farmers with Anatolian-derived ancestry arrived. Although the Neolithic transition was delayed by more than a millennium relative to Central Europe, it was very abrupt and resulted in a population turnover with limited genetic contribution from local hunter-gatherers. The succeeding Neolithic population, associated with the Funnel Beaker culture, persisted for only about 1,000 years before immigrants with eastern Steppe-derived ancestry arrived. This second and equally rapid population replacement gave rise to the Single Grave culture with an ancestry profile more similar to present-day Danes. In our multiproxy dataset, these major demographic events are manifested as parallel shifts in genotype, phenotype, diet and land use.
(© 2024. The Author(s).)
Databáze: MEDLINE
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