Swine models in translational research and medicine.
| Autor: | Meyerholz DK; University of Iowa, Iowa City, IA., Burrough ER; Iowa State University, Ames, IA., Kirchhof N; Medtronic, Inc., Minneapolis, MN., Anderson DJ; The University of Alabama at Birmingham, Birmingham, AL., Helke KL; Medical University of South Carolina, Charleston, SC. |
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| Jazyk: | angličtina |
| Zdroj: | Veterinary pathology [Vet Pathol] 2024 Jul; Vol. 61 (4), pp. 512-523. Date of Electronic Publication: 2024 Jan 10. |
| DOI: | 10.1177/03009858231222235 |
| Abstrakt: | Swine are increasingly studied as animal models of human disease. The anatomy, size, longevity, physiology, immune system, and metabolism of swine are more like humans than traditional rodent models. In addition, the size of swine is preferred for surgical placement and testing of medical devices destined for humans. These features make swine useful for biomedical, pharmacological, and toxicological research. With recent advances in gene-editing technologies, genetic modifications can readily and efficiently be made in swine to study genetic disorders. In addition, gene-edited swine tissues are necessary for studies testing and validating xenotransplantation into humans to meet the critical shortfall of viable organs versus need. Underlying all of these biomedical applications, the knowledge of husbandry, background diseases and lesions, and biosecurity needs are important for productive, efficient, and reproducible research when using swine as a human disease model for basic research, preclinical testing, and translational studies. Competing Interests: Declaration of Conflicting InterestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. |
| Databáze: | MEDLINE |
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