Longitudinal changes in iron homeostasis in human experimental and clinical malaria.

Autor:	Woolley SD; Infection and Inflammation Program, QIMR Berghofer Medical Research Institute, Brisbane, Australia.; Clinical Sciences Department, Liverpool School of Tropical Medicine, Liverpool, United Kingdom.; Academic Department of Military Medicine, Royal Centre for Defence Medicine, Birmingham, United Kingdom., Grigg MJ; Global and Tropical Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, Australia.; Infectious Diseases Society Kota Kinabalu Sabah-Menzies School of Health Research Clinical Research Unit, Kota Kinabalu, Malaysia., Marquart L; Infection and Inflammation Program, QIMR Berghofer Medical Research Institute, Brisbane, Australia.; School of Public Health, University of Queensland, Brisbane, Australia., Gower J; Infection and Inflammation Program, QIMR Berghofer Medical Research Institute, Brisbane, Australia., Piera K; Global and Tropical Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, Australia., Nair AS; Infection and Inflammation Program, QIMR Berghofer Medical Research Institute, Brisbane, Australia., Amante FM; Infection and Inflammation Program, QIMR Berghofer Medical Research Institute, Brisbane, Australia., Rajahram GS; Infectious Diseases Society Kota Kinabalu Sabah-Menzies School of Health Research Clinical Research Unit, Kota Kinabalu, Malaysia.; Department of Medicine, Queen Elizabeth II Hospital, Kota Kinabalu, Malaysia.; Clinical Research Centre, Queen Elizabeth Hospital, Kota Kinabalu, Malaysia., William T; Infectious Diseases Society Kota Kinabalu Sabah-Menzies School of Health Research Clinical Research Unit, Kota Kinabalu, Malaysia.; Department of Medicine, Queen Elizabeth II Hospital, Kota Kinabalu, Malaysia.; Subang Jaya Medical Centre, Subang Jaya, Malaysia., Frazer DM; Infection and Inflammation Program, QIMR Berghofer Medical Research Institute, Brisbane, Australia., Chalon S; Medicines for Malaria Venture, Geneva, Switzerland., McCarthy JS; Infection and Inflammation Program, QIMR Berghofer Medical Research Institute, Brisbane, Australia.; Victorian Infectious Diseases Institute, Peter Doherty Institute, University of Melbourne, Melbourne, Australia., Anstey NM; Global and Tropical Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, Australia.; Infectious Diseases Society Kota Kinabalu Sabah-Menzies School of Health Research Clinical Research Unit, Kota Kinabalu, Malaysia., Barber BE; Infection and Inflammation Program, QIMR Berghofer Medical Research Institute, Brisbane, Australia.; Global and Tropical Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, Australia.; Infectious Diseases Society Kota Kinabalu Sabah-Menzies School of Health Research Clinical Research Unit, Kota Kinabalu, Malaysia.; Infectious Diseases Department, Royal Brisbane and Women's Hospital, Brisbane, Australia.
Jazyk:	angličtina
Zdroj:	MedRxiv : the preprint server for health sciences [medRxiv] 2023 Dec 21. Date of Electronic Publication: 2023 Dec 21.
DOI:	10.1101/2023.12.19.23300265
Abstrakt:	Background: The interaction between iron deficiency and malaria is incompletely understood. We evaluated longitudinal changes in iron homeostasis in volunteers enrolled in malaria volunteer infection studies (VIS) and in Malaysian patients with falciparum and vivax malaria. Methods: We retrieved samples and associated data from 55 participants enrolled in malaria VIS, and 171 malaria patients and 30 healthy controls enrolled in clinical studies in Malaysia. Ferritin, hepcidin, erythropoietin, and soluble transferrin receptor (sTfR) were measured by ELISA. Results: In the VIS, participants' parasitaemia was correlated with baseline mean corpuscular volume (MCV), but not iron status (ferritin, hepcidin or sTfR). Ferritin, hepcidin and sTfR all increased during the VIS. Ferritin and hepcidin normalised by day 28, while sTfR remained elevated. In VIS participants, baseline iron status (ferritin) was associated with post-treatment increases in liver transaminase levels. In Malaysian malaria patients, hepcidin and ferritin were elevated on admission compared to healthy controls, while sTfR increased following admission. Hepcidin normalised by day 28; however, ferritin and sTfR both remained elevated 4 weeks following admission. Conclusion: Our findings demonstrate that parasitaemia is associated with an individual's MCV rather than iron status. The persistent elevation in sTfR 4 weeks post-infection in both malaria VIS and clinical malaria may reflect a causal link between malaria and iron deficiency. Competing Interests: Declaration of interests None of the authors have conflicts of interests to declare.
Databáze:	MEDLINE
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