ALCAM is a biomarker of tumor aggressiveness and worse prognosis in glottic laryngeal squamous cell carcinoma.

Autor: Nicolau-Neto P; Programa de Carcinogênese Molecular, Instituto Nacional de Câncer-INCA, Rio de Janeiro, Brazil., Peryassú BC; Seção de Cirurgia de Cabeça e Pescoço, Instituto Nacional de Câncer-INCA, Rio de Janeiro, Brazil., de Carvalho FN; Programa de Carcinogênese Molecular, Instituto Nacional de Câncer-INCA, Rio de Janeiro, Brazil., Souza-Santos PT; Biologia Molecular, Beneficência Portuguesa de São Paulo, São Paulo, Brazil., Valverde P; Divisão de Patologia, Instituto Nacional de Câncer-INCA, Rio de Janeiro, Brazil., Nascimento CM; Divisão de Patologia, Instituto Nacional de Câncer-INCA, Rio de Janeiro, Brazil., Costa I; Seção de Cirurgia de Cabeça e Pescoço, Instituto Nacional de Câncer-INCA, Rio de Janeiro, Brazil., Dias FL; Seção de Cirurgia de Cabeça e Pescoço, Instituto Nacional de Câncer-INCA, Rio de Janeiro, Brazil., Pinto LFR; Programa de Carcinogênese Molecular, Instituto Nacional de Câncer-INCA, Rio de Janeiro, Brazil.; Departamento de Bioquímica, Instituto de Biologia Roberto Alcântara Gomes, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil.
Jazyk: angličtina
Zdroj: Head & neck [Head Neck] 2024 Apr; Vol. 46 (4), pp. 785-796. Date of Electronic Publication: 2024 Jan 09.
DOI: 10.1002/hed.27635
Abstrakt: Background: Laryngeal squamous cell carcinoma (LSCC) is the second most frequent head and neck tumor. Prognosis of patients with LSCC has not improved in recent decades, showing a need for the identification of prognostic biomarkers and new therapeutic targets. Recently, we showed that ALCAM overexpression was associated with glottic LSCC prognosis.
Objectives and Methods: Aiming to validate the prognostic value of ALCAM, we evaluate the ALCAM protein levels by immunohistochemistry in 263 glottic LSCC surgically treated with neck dissection.
Results: ALCAM was expressed in 48.7% and overexpressed in 36.5% of glottic LSCC samples. ALCAM overexpression was associated with lymph node metastasis (p = 0.030), lymphovascular involvement (p = 0.0002), high-grade tumors (p = 0.025), and tumor relapse (p = 0.043). Multivariate survival analyses showed an overfitting between ALCAM overexpression and lymph node metastasis as a prognostic variable.
Conclusions: High ALCAM expression was associated with an aggressive glottic LSCC profile.
(© 2024 Wiley Periodicals LLC.)
Databáze: MEDLINE
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