Central blockage of sympathetic nerves inhibits the abnormal vital signs and disturbance of the gut microbiota caused by continuous light exposure.
| Autor: | Zhao Y; Qinghai University, Xining 810001, China., Ma XM; Department of Cardiology, Gansu Provincial Hospital, Lanzhou, Gansu 730000, China., Ren M; Department of Cardiology, Affiliated Hospital of Qinghai University, Xining, Qinghai 810001, China., Liu H; Department of Cardiology, Affiliated Hospital of Qinghai University, Xining, Qinghai 810001, China., Duan HL; Qinghai University, Xining 810001, China., Liu XL; Qinghai University, Xining 810001, China., Gao ZS; Qinghai University, Xining 810001, China., Ma YL; Qinghai Cardio-Cerebrovascular Specialty Hospital, Qinghai High Altitude Medical Research Institute, Xining, 810012, China. |
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| Jazyk: | angličtina |
| Zdroj: | Heliyon [Heliyon] 2023 Nov 30; Vol. 10 (1), pp. e22742. Date of Electronic Publication: 2023 Nov 30 (Print Publication: 2024). |
| DOI: | 10.1016/j.heliyon.2023.e22742 |
| Abstrakt: | Background: Continuous light exposure increases sympathetic excitation in rats, leading to hypertension, left ventricular hypertrophy, and fibrosis. This study was aimed to investigate whether continuous light exposure causes destabilization of vital signs and gut microbiota (GM) in Sprague Dawley (SD) rats and whether clonidine hydrochloride (CH), a central sympathetic depressant drug, could prevent these changes. Methods: Eight-week-old male SD rats were divided into three groups with different interventions for 14 weeks: control group (CG), 2-mL pure water gavaged daily while on a normal 12-h light/dark cycle; continuous illumination group (CI), 2-mL pure water gavaged daily while receiving continuous exposure to light (300 lx); and drug administration group (DA), CH (10 μg/kg) gavaged daily while receiving continuous exposure to light (300 lx). Results: The results showed that blood pressure, heart rate, and body weight were significantly higher in the CI group than in the CG and DA groups (P < 0.05). Moreover, the Shannon index was higher in the DA group than in the CI group (P = 0.012). The beta diversity index in the CG group was significantly higher in the CI group (P = 0.039). The pairwise comparison results of the linear discriminant analysis effect size showed that Oscillospirales were enriched in the DA group, whereas the Prevotellaceae lineage (family level) > Prevotella (genus level) > Prevotellaceae _bacterium (species level) were enriched in the CI group. The Muribaculaceae family was more abundant in the CG group than in the CI group. Conclusion: Sympathetic nerve inhibition restored the abnormal vital signs and GM changes under continuous light exposure. Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (© 2023 Published by Elsevier Ltd.) |
| Databáze: | MEDLINE |
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