Lactoferrin intake from maternal milk during the neonatal hospitalization and early brain development among preterm infants.

Autor: Atayde AMP; Department of Pediatrics, Division of Newborn Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Harvard T.H. Chan School of Public Health, Boston, MA, USA., Kapoor NR; Harvard T.H. Chan School of Public Health, Boston, MA, USA., Cherkerzian S; Department of Pediatrics, Division of Newborn Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Olson I; Department of Pediatrics, Division of Newborn Medicine, Brigham and Women's Hospital, Boston, MA, USA., Andrews C; Department of Pediatrics, Division of Newborn Medicine, Brigham and Women's Hospital, Boston, MA, USA., Lee ACC; Department of Pediatrics, Division of Newborn Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Sen S; Department of Pediatrics, Division of Newborn Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Bode L; Department of Pediatrics, LRF Mother-Milk-Infant Center of Research Excellence (MOMI CORE), Human Milk Institute (HMI), University of California, San Diego, La Jolla, CA, USA., George K; Department of Pediatrics, Division of Newborn Medicine, Brigham and Women's Hospital, Boston, MA, USA., Bell K; Department of Pediatrics, Division of Newborn Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Inder T; Children's Hospital, Orange County, University of California, Irvine, CA, USA., Belfort MB; Department of Pediatrics, Division of Newborn Medicine, Brigham and Women's Hospital, Boston, MA, USA. mbelfort@bwh.harvard.edu.; Harvard Medical School, Boston, MA, USA. mbelfort@bwh.harvard.edu.
Jazyk: angličtina
Zdroj: Pediatric research [Pediatr Res] 2024 Jul; Vol. 96 (1), pp. 159-164. Date of Electronic Publication: 2024 Jan 08.
DOI: 10.1038/s41390-023-03002-5
Abstrakt: Background: Lactoferrin is an immuno-modulatory nutrient in human milk that may be neuroprotective.
Methods: In 36 infants born <32 weeks' gestation, we sampled human milk at 14 and 28 days of chronologic age and measured lactoferrin by electrochemiluminescence multiplex immunoassay. Using 3T quantitative brain magnetic resonance imaging scans obtained at term equivalent, we estimated total and regional brain volumes. We compared outcomes between infants exposed to low (bottom tertile, range 0.06-0.13 mg/mL) vs. high (top tertile, range 0.22-0.35 mg/mL) lactoferrin using median regression in models adjusted for gestational age, birth weight z-score, sex, and postmenstrual age.
Results: Compared to infants exposed to low lactoferrin, infants exposed to high lactoferrin had 43.9 cc (95% CI: 7.6, 80.4) larger total brain volume, 48.3 cc (95% CI: 12.1, 84.6) larger cortical gray matter, and 3.8 cc (95% CI: 0.7, 7.0) larger deep gray matter volume at term equivalent age. Other regional brain volumes were not statistically different between groups.
Conclusion: Higher lactoferrin exposure during the neonatal hospitalization was associated with larger total brain and gray matter volumes, suggesting that lactoferrin may have potential as a dietary supplement to enhance brain growth in the neonatal intensive care unit setting.
Impact: This study suggests that lactoferrin, a whey protein found in human milk, may be beneficial for preterm infant brain development, and therefore has potential as a dietary supplement in the neonatal intensive care unit setting.
(© 2024. The Author(s), under exclusive licence to the International Pediatric Research Foundation, Inc.)
Databáze: MEDLINE
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