Prevalence and associations of multiple hypnotic prescriptions in a clinical sample.

Autor:	Kolla BP; Department of Psychiatry and Psychology, Mayo Clinic, Rochester, Minnesota.; Center for Sleep Medicine, Mayo Clinic, Rochester, Minnesota., Mansukhani MP; Center for Sleep Medicine, Mayo Clinic, Rochester, Minnesota., Chakravorty S; Perelman School of Medicine, Philadelphia, Pennsylvania., Frank JA; Department of Quantitative Health Sciences, Division of Computational Biology, Mayo Clinic, Rochester, Minnesota., Coombes BJ; Department of Quantitative Health Sciences, Division of Computational Biology, Mayo Clinic, Rochester, Minnesota.
Jazyk:	angličtina
Zdroj:	Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine [J Clin Sleep Med] 2024 May 01; Vol. 20 (5), pp. 793-800.
DOI:	10.5664/jcsm.10988
Abstrakt:	Study Objectives: We examined the prevalence of multiple hypnotic prescriptions and its association with clinical and demographic characteristics from the electronic health record (EHR) in the Mayo Clinic Biobank. Methods: Adult participants enrolled in the Mayo Clinic Biobank with an EHR number of ≥ 1 year were included (n = 52,940). Clinical and demographic characteristics were compared between participants who were and were not prescribed any hypnotic approved for insomnia by the US Food and Drug Administration and/or trazodone and in those prescribed a single vs multiple (≥ 2) hypnotics. A phenotype-based, phenome-wide association study (PheWAS) examining associations between hypnotic prescriptions and diagnoses across the EHR was performed adjusting for demographic and other confounders. Results: A total of 17,662 (33%) participants were prescribed at least 1 hypnotic and 5,331 (10%) received ≥ 2 hypnotics. Participants who were prescribed a hypnotic were more likely to be older, female, White, with a longer EHR, and a greater number of diagnostic codes (all P < .001). Those with multiple hypnotic prescriptions were more likely to be younger, female, with a longer EHR, and a greater number of diagnostic codes (all P < .001) compared with those prescribed a single hypnotic. The PheWAS revealed that participants with multiple hypnotic prescriptions had higher rates of mood disorders, anxiety disorders, suicidal ideation, restless legs syndrome, and chronic pain (all P < 1 e -10 ). Conclusions: Receiving multiple hypnotic prescriptions is common and associated with a greater prevalence of psychiatric, chronic pain, and sleep-related movement disorders. Future studies should examine potential genetic associations with multiple hypnotic prescriptions to personalize treatments for chronic insomnia. Citation: Kolla BP, Mansukhani MP, Chakravorty S, Frank JA, Coombes BJ. Prevalence and associations of multiple hypnotic prescriptions in a clinical sample. J Clin Sleep Med . 2024;20(5):793-800. (© 2024 American Academy of Sleep Medicine.)
Databáze:	MEDLINE
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