Clinical and neuroimaging factors associated with 30-day fatality among indigenous West Africans with spontaneous intracerebral hemorrhage.

Autor: Komolafe MA; Department of Medicine, Obafemi Awolowo University, Ile-Ife, Osun State, Nigeria., Sunmonu T; Department of Medicine, Federal Medical Centre, Owo, Ondo State, Nigeria., Akinyemi J; Department of Epidemiology and Medical Statistics, College of Medicine, University of Ibadan, Nigeria., Sarfo FS; Department of Medicine, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana., Akpalu A; Department of Medicine, University of Ghana Medical School, Accra, Ghana., Wahab K; Department of Medicine, University of Ilorin Teaching Hospital, Ilorin, Nigeria., Obiako R; Department of Medicine, Ahmadu Bello University, Zaria, Nigeria., Owolabi L; Department of Medicine, Aminu Kano Teaching Hospital, Kano, Nigeria., Osaigbovo GO; Jos University Teaching Hospital, Jos, Nigeria., Ogbole G; Department of Radiology, University of Ibadan, Nigeria., Tiwari HK; University of Alabama at Birmingham, Birmingham, AL, USA., Jenkins C; Medical University of South Carolina, SC, USA., Lackland DT; Medical University of South Carolina, SC, USA., Fakunle AG; College of Medicine, University of Ibadan, Nigeria., Uvere E; College of Medicine, University of Ibadan, Nigeria., Akpa O; Department of Epidemiology and Medical Statistics, College of Medicine, University of Ibadan, Nigeria., Dambatta HA; Department of Medicine, Aminu Kano Teaching Hospital, Kano, Nigeria., Akpalu J; Department of Medicine, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana., Onasanya A; Department of Medicine, Federal Medical Centre, Abeokuta, Nigeria., Olaleye A; Department of Medicine, University of Ilorin Teaching Hospital, Ilorin, Nigeria., Ogah OS; University College Hospital, Ibadan, Nigeria., Isah SY; Department of Medicine, Aminu Kano Teaching Hospital, Kano, Nigeria., Fawale MB; Department of Medicine, Obafemi Awolowo University, Ile-Ife, Osun State, Nigeria., Adebowale A; Department of Medicine, Obafemi Awolowo University, Ile-Ife, Osun State, Nigeria., Okekunle AP; Department of Epidemiology and Medical Statistics, College of Medicine, University of Ibadan, Nigeria., Arnett D; College of Public Health, University of Kentucky, USA., Adeoye AM; University College Hospital, Ibadan, Nigeria., Agunloye AM; Department of Radiology, University of Ibadan, Nigeria., Bello AH; Department of Medicine, University of Ilorin Teaching Hospital, Ilorin, Nigeria., Aderibigbe AS; Department of Radiology, Obafemi Awolowo University, Ile-Ife, Osun State, Nigeria., Idowu AO; Department of Medicine, Obafemi Awolowo University, Ile-Ife, Osun State, Nigeria., Sanusi AA; Department of Medicine, Obafemi Awolowo University, Ile-Ife, Osun State, Nigeria., Ogunmodede A; Department of Medicine, Obafemi Awolowo University, Ile-Ife, Osun State, Nigeria., Balogun SA; Department of Surgery, Obafemi Awolowo University Teaching Hospital Complex, Ile-Ife, Osun State, Nigeria., Egberongbe AA; Department of Medicine, Federal Medical Centre, Owo, Ondo State, Nigeria., Rotimi FT; Department of Medicine, Federal Medical Centre, Owo, Ondo State, Nigeria., Fredrick A; Department of Medicine, Federal Medical Centre, Owo, Ondo State, Nigeria., Akinnuoye AO; Department of Medicine, Federal Medical Centre, Owo, Ondo State, Nigeria., Adeniyi FA; Department of Medicine, Federal Medical Centre, Owo, Ondo State, Nigeria., Calys-Tagoe B; Department of Community Health, University of Ghana Medical School, Accra, Ghana., Adebayo P; Aga-Khan University, Dar es Salaam, Tanzania., Arulogun O; College of Medicine, University of Ibadan, Nigeria., Agbogu-Ike OU; Department of Medicine, Ahmadu Bello University, Zaria, Nigeria., Yaria J; University College Hospital, Ibadan, Nigeria., Appiah L; Department of Medicine, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana., Ibinaiye P; Department of Medicine, Ahmadu Bello University, Zaria, Nigeria., Singh A; Department of Medicine, University of Ghana Medical School, Accra, Ghana., Adeniyi S; Department of Medicine, University of Ghana Medical School, Accra, Ghana., Olalusi O; University College Hospital, Ibadan, Nigeria., Mande A; Department of Medicine, Aminu Kano Teaching Hospital, Kano, Nigeria., Balogun O; Department of Medicine, Ahmadu Bello University, Zaria, Nigeria., Akinyemi R; University College Hospital, Ibadan, Nigeria; Federal Medical Centre, Abeokuta, Nigeria., Ovbiagele B; Weill Institute for Neurosciences, School of Medicine, University of California, San-Francisco, USA., Owolabi M; University College Hospital, Ibadan, Nigeria; Center for Genomic and Precision Medicine, College of Medicine, University of Ibadan, Nigeria. Electronic address: mayowaowolabi@yahoo.com.
Jazyk: angličtina
Zdroj: Journal of the neurological sciences [J Neurol Sci] 2024 Jan 15; Vol. 456, pp. 122848. Date of Electronic Publication: 2023 Dec 20.
DOI: 10.1016/j.jns.2023.122848
Abstrakt: Background: Spontaneous intracerebral hemorrhage (ICH) is associated with a high case fatality rate in resource-limited settings. The independent predictors of poor outcome after ICH in sub-Saharan Africa remains to be characterized in large epidemiological studies. We aimed to determine factors associated with 30-day fatality among West African patients with ICH.
Methods: The Stroke Investigative Research and Educational Network (SIREN) study is a multicentre, case-control study conducted at 15 sites in Nigeria and Ghana. Adults aged ≥18 years with spontaneous ICH confirmed with neuroimaging. Demographic, cardiovascular risk factors, clinical features and neuroimaging markers of severity were assessed. The independent risk factors for 30-day mortality were determined using a multivariate logistic regression analysis with an adjusted odds ratio (OR) and 95% confidence interval (CI).
Results: Among 964 patients with ICH, 590 (61.2%) were males with a mean age (SD) of 54.3(13.6) years and a case fatality of 34.3%. Factors associated with 30-day mortality among ICH patients include: Elevated mean National Institute of Health Stroke Scale(mNIHSS);(OR 1.06; 95% CI 1.02-1.11), aspiration pneumonitis; (OR 7.17; 95% CI 2.82-18.24), ICH volume > 30mls; OR 2.68; 95% CI 1.02-7.00)) low consumption of leafy vegetables (OR 0.36; 95% CI 0.15-0.85).
Conclusion: This study identified risk and protective factors associated with 30-day mortality among West Africans with spontaneous ICH. These factors should be further investigated in other populations in Africa to enable the development of ICH mortality predictions models among indigenous Africans.
Competing Interests: Declaration of Competing Interest The authors declare that there are no conflicts of interests with the article. The article was written according to recommendation from International Committee of Medical Journals Editors.
(Copyright © 2023 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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