In vivo exposure to electronic waste (e-waste) leachate and hydraulic fracturing fluid adversely impacts the male reproductive system.

Autor: Raja A; Division of Environmental Medicine, New York University School of Medicine, New York, NY, USA., Costa P; Division of Environmental Medicine, New York University School of Medicine, New York, NY, USA., Blum JL; Division of Environmental Medicine, New York University School of Medicine, New York, NY, USA; Product Safety Labs, Dayton, NJ, USA., Doherty-Lyons S; Division of Environmental Medicine, New York University School of Medicine, New York, NY, USA., Igbo JK; Department of Biological Oceanography, Nigerian Institute for Oceanography and Marine Research, Lagos, Nigeria., Meltzer G; Departments of Epidemiology and Environmental Health Sciences, Columbia University Mailman School of Public Health, New York, NY, USA., Orem W; United States Geological Survey, Reston, VA, USA., McCawley M; Department of Occupational & Environmental Health Sciences, School of Public Health, West Virginia University, South Morgantown, WV, USA., Zelikoff JT; Division of Environmental Medicine, New York University School of Medicine, New York, NY, USA. Electronic address: Judith.Zelikoff@nyulangone.org.
Jazyk: angličtina
Zdroj: Reproductive toxicology (Elmsford, N.Y.) [Reprod Toxicol] 2024 Mar; Vol. 124, pp. 108533. Date of Electronic Publication: 2023 Dec 30.
DOI: 10.1016/j.reprotox.2023.108533
Abstrakt: Human health effects can arise from unregulated manual disassembly of electronic waste (e-waste) and/or hydraulic fracturing fluid spills. There is limited literature on the effects of e-waste and hydraulic fracturing wastewater exposure on the male reproductive system. Thus, this proof-of-concept study begins to address the question of how wastewater from two potentially hazardous environmental processes could affect sperm quality. Therefore, three groups of eight-week-old adult mice were exposed (5 d/wk for 6 wks) via a mealworm (Tenebrio molitor and Zophabas morio) feeding route to either: (1) e-waste leachate (50% dilution) from the Alaba Market (Lagos, Nigeria); (2) West Virginia hydraulic fracturing flowback (HFF) fluid (50% dilution); or, (3) deionized water (control). At 24-hours (hr), 3 weeks (wk), or 9-wk following the 6-wk exposure period, cohorts of mice were necropsied and adverse effects/persistence on the male reproductive system were examined. Ingestion of e-waste leachate or HFF fluid decreased number and concentration of sperm and increased both chromatin damage and numbers of morphological abnormalities in the sperm when compared to control mice. Levels of serum testosterone were reduced post-exposure (3- and 9-wk) in mice exposed to e-waste leachate and HFF when compared to time-matched controls, indicating the long-term persistence of adverse effects, well after the end of exposure. These data suggest that men living around or working in vicinity of either e-waste or hydraulic fracturing could face harmful effects to their reproductive health. From both a human health and economic standpoint, development of prevention and intervention strategies that are culturally relevant and economically sensitive are critically needed to reduce exposure to e-waste and HFF-associated toxic contaminants.
Competing Interests: Declaration of Competing Interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Judith T. Zelikoff reports financial support was provided by NIEHS.
(Copyright © 2024 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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