Risk of stroke the year following a delivery after using assisted reproductive technologies.

Autor: Magnus MC; Centre for Fertility and Health, Norwegian Institute of Public Health, Oslo, Norway., Håberg SE; Centre for Fertility and Health, Norwegian Institute of Public Health, Oslo, Norway.; Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway., Rönö K; Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland., Romundstad LB; Spiren Fertility Clinic, Trondheim, Norway., Bergh C; Department of Obstetrics and Gynecology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.; Region Västra Götaland, Sahlgrenska University Hospital, Gothenburg, Sweden., Spangmose AL; Fertility Department, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark., Pinborg A; Fertility Department, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark., Gissler M; Finnish Institute for Health and Welfare, Helsinki, Finland.; Region Stockholm, Academic Primary Health Care Centre, Stockholm, Sweden.; Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden., Wennerholm UB; Department of Obstetrics and Gynecology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.; Region Västra Götaland, Sahlgrenska University Hospital, Gothenburg, Sweden., Opdahl S; Department of Public Health and Nursing, Norwegian University of Science and Technology, Trondheim, Norway.; Centre for Big Data Research in Health, University of New South Wales, Kensington, Australia.
Jazyk: angličtina
Zdroj: Paediatric and perinatal epidemiology [Paediatr Perinat Epidemiol] 2024 Mar; Vol. 38 (3), pp. 197-201. Date of Electronic Publication: 2023 Dec 29.
DOI: 10.1111/ppe.13037
Abstrakt: Background: Studies indicate that individuals who deliver after assisted reproductive technologies (ART) may have an increased risk of cardiovascular disease (CVD). A recent large study from the U.S. showed a higher risk of stroke during the first year after delivery.
Objectives: To compare the risk of stroke during the first year after delivery according to the use of ART in the Nordic countries.
Methods: Registry-based cohort study using nationwide data from Denmark (1994-2014), Finland (1990-2014), Norway (1984-2015) and Sweden (1985-2015). Data on ART conception were available from ART quality registries and/or Medical Birth Registries (MBRs). National data on stroke were available from hospital and cause-of-death registries. The risk of stroke during the first year after delivery was estimated with Cox proportional hazard regression, adjusting for age, calendar year of delivery, multiple births, and country.
Results: A total of 2,659,272 primiparous individuals had a registered delivery in the MBRs during the study period, and 91,466 (4%) of these gave birth after ART. We observed no overall increased risk of stroke during the first year after delivery among individuals conceiving after ART (adjusted hazard ratio [HR] 1.10, 95% CI 0.77, 1.57). Similarly, there was no convincing evidence that the short-term risk of stroke was higher within 1, 2, 3, or 6 months after delivery, with adjusted HRs ranging between 1.23 and 1.33 and confidence intervals including the null value for all time periods. A secondary analysis also including multiparous individuals (n = 3,335,478) at the start of follow-up yielded similar findings.
Conclusions: We found no evidence of an increased short-term risk of stroke among individuals who delivered after using ART.
(© 2023 The Authors. Paediatric and Perinatal Epidemiology published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
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