Economic and Productive Comparison of Rutin and Rutin-Loaded Chitosan Alginate Nanoparticles Against Lead-Induced Oxidative Stress in Cobb and Arbor Broiler Breeds.

Autor: Wahed NM; Department of Animal Wealth Development, Faculty of Veterinary Medicine, Mansoura University, Mansoura, 35516, Egypt., Abomosallam M; Department of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, Mansoura University, Mansoura, 35516, Egypt. mohamedabomosallam@mans.edu.eg., Hendam BM; Department of Animal Wealth Development, Faculty of Veterinary Medicine, Mansoura University, Mansoura, 35516, Egypt., Shouman Z; Department of Cytology and Histology, Faculty of Veterinary Medicine, Mansoura University, Mansoura, 35516, Egypt., Hashem NM; Department of Physiology, Faculty of Veterinary Medicine, Mansoura University, Mansoura, 35516, Egypt., Sakr SA; Department of Animal Wealth Development, Faculty of Veterinary Medicine, Mansoura University, Mansoura, 35516, Egypt.
Jazyk: angličtina
Zdroj: Biological trace element research [Biol Trace Elem Res] 2024 Oct; Vol. 202 (10), pp. 4715-4734. Date of Electronic Publication: 2023 Dec 28.
DOI: 10.1007/s12011-023-04019-x
Abstrakt: Rutin, a natural bioflavonoid compound, is one of the best-known antioxidants. This study aimed to investigate the protective effect of rutin-loaded chitosan alginate nanoparticles (RCA NPs) against lead (Pb)-induced oxidative stress in two different broiler breeds. A total number of 240 chicks from Cobb (CB) and Arbor Acres (AR) breeds were randomly allocated into 4 groups/breed. The 1 st group received standard basal diet (SD) and drinking water (DW) while the 2 nd group received SD and Pb-incorporated DW (350 mg/L). The 3 rd group treated with both rutin-supplemented SD (50 mg/kg feed), and DW contain Pb (350 mg/L). Finally, the 4 th group administered RCA NPs-supplemented SD (50 mg/kg feed) and Pb-incorporated DW (350 mg/L). On the 40 th day of experiment, broilers weighed, and blood samples collected for biochemical and hematological analysis then slaughtered. Economic efficiency, growth performance, and oxidative stress biomarkers were evaluated. Gene expression level of growth-associated genes as insulin-like growth factor-I (IGF-1) and histopathological changes were assessed in liver and intestinal tissue of both breeds. Our results revealed that Pb-treated birds exhibited the lowest average body weight gain (BWG) and economic efficiency measures in both breeds while RCA NPs-treated groups revealed enhanced growth and economic performance. Furthermore, diet supplementation with RCA NPs considerably enhanced the antioxidant enzymes activity and expression of growth-associated genes than groups treated with rutin alone specifically in AR breed. In conclusion, RCA NPs supplementation could be a promising nanoformulation in poultry production through enhancing the antioxidant capacity and bioavailability of rutin.
(© 2023. The Author(s).)
Databáze: MEDLINE
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