Intensive Weight-Loss Lifestyle Intervention Using Mediterranean Diet and COVID-19 Risk in Older Adults: Secondary Analysis of PREDIMED-Plus Trial.

Autor: Shyam S; Prof Jordi Salas-Salvadó and Dr Sangeetha Shyam, Universitat Rovira i Virgili, Departament de Bioquímica i Biotecnologia, Food, Nutrition, Development and Mental Health Group (ANUT-DSM), Human Nutrition Unit. C/Sant Llorenç 21, 43201, Reus, Spain. Email: jordi.salas@urv.cat and Sangeetha.shyam@urv.cat., García-Gavilán JF, Paz-Graniel I, Gaforio JJ, Martínez-González MÁ, Corella D, Martínez JA, Alonso-Gómez ÁM, Wärnberg J, Vioque J, Romaguera D, López-Miranda J, Estruch R, Tinahones FJ, Lapetra J, Serra-Majem JL, Bueno-Cavanillas A, Tur JA, Martín Sánchez V, Pintó X, Matía-Martín P, Vidal J, Del Mar Alcarria M, Daimiel L, Ros E, Fernandez-Aranda F, Nishi SK, García-Regata Ó, Perez Araluce R, Asensio EM, Castañer O, Garcia-Rios A, Oncina-Cánovas A, Bouzas C, Zulet MA, Rayó E, Casas R, Martin-Pelaez S, Tojal-Sierra L, Bernal-López MR, Carlos S, Sorlí JV, Goday A, Peña-Orihuela PJ, Pastor-Morel A, Eguaras S, Zomeño MD, Delgado-Rodríguez M, Babio N, Fitó M, Salas-Salvadó J
Jazyk: angličtina
Zdroj: The journal of nutrition, health & aging [J Nutr Health Aging] 2023; Vol. 27 (12), pp. 1162-1167.
DOI: 10.1007/s12603-023-2044-4
Abstrakt: Objectives: We tested the effects of a weight-loss intervention encouraging energy-reduced MedDiet and physical activity (PA) in comparison to ad libitum MedDiet on COVID-19 incidence in older adults.
Design: Secondary analysis of PREDIMED-Plus, a prospective, ongoing, multicentre randomized controlled trial.
Setting: Community-dwelling, free-living participants in PREDIMED-Plus trial.
Participants: 6,874 Spanish older adults (55-75 years, 49% women) with overweight/obesity and metabolic syndrome.
Intervention: Participants were randomised to Intervention (IG) or Control (CG) Group. IG received intensive behavioural intervention for weight loss with an energy-reduced MedDiet intervention and PA promotion. CG was encouraged to consume ad libitum MedDiet without PA recommendations.
Measurements: COVID-19 was ascertained by an independent Event Committee until December 31, 2021. COX regression models compared the effect of PREDIMED-Plus interventions on COVID-19 risk.
Results: Overall, 653 COVID-19 incident cases were documented (IG:317; CG:336) over a median (IQR) follow-up of 5.8 (1.3) years (inclusive of 4.0 (1.2) years before community transmission of COVID-19) in both groups. A significantly lowered risk of COVID-19 incidence was not evident in IG, compared to CG (fully-adjusted HR (95% CI): 0.96 (0.81,1.12)).
Conclusions: There was no evidence to show that an intensive weight-loss intervention encouraging energy-reduced MedDiet and PA significantly lowered COVID-19 risk in older adults with overweight/obesity and metabolic syndrome in comparison to ad libitum MedDiet. Recommendations to improve adherence to MedDiet provided with or without lifestyle modification suggestions for weight loss may have similar effects in protecting against COVID-19 risk in older adults with high cardiovascular risks.
Competing Interests: Fernandez-Aranda acknowledges consulting fees from Novo Nordisk and Wiley as EIC for the European Eat Dis Rev. He has also received honoraria for lectures and support for travel/meetings from Novo Nordisk. He discloses his honorary participation in the Data Safety Monitoring Board or Advisory Board of Sustain-Consortium-Germany. Emilio Ros has received honoraria for presentations and support for attending meetings/travel from the California Walnut Commission, Alexion and the Spanish Atherosclerosis Society. He has also received consulting fees from Alexion. He participates in the Data Safety Monitoring Board or Advisory Board of the PREDIMED-Plus Clinical Trial. Ramon Estruch has received research grants from Instituto de Salud Carlos III, Madrid, Spain. He has received honoraria for presentations from Fundacion Cerveza y Salud, Spain; Instituto Cervantes, Albuquerque, USA; Instituto Cervantes, Milan, Italy; Instituto Cervantes, Tokyo, Japan; Fundacion Bosch i Gimpera, Spain; Wine and Culinary International Forum; Pernaud Richart; Mexico; Fundacion Dieta Mediterranea, Barcelona, Spain. He has received support for travel or meetings or conference organization from ERAB, Belgium, Brewers of Europe, Belgium, and Sociedad Española de Nutrición (SEN). He has served on the Advisory Board of Cerveza y Salud, Spain. Jordi Salas-Salvadó reported receiving consulting fees from Eroski Foundation. He has also received grants and support for attending meetings/travel from Nut and Dried Fruit Foundation. He is an honorary Member of the International Advisory Board of the Project “Effect of cashew nut supplementation on glycemic status and lipid profile in type 2 diabetes subjects”, Member of the Scientific Advisory Committee of the European PEGASO project (Personalized Guidance Services for Optimizing lifestyle management in teenagers through awareness, motivation and engagement) and Member of the Scientific Committee of Danone Institute International. He received personal fees for serving as a Member of the Institute Danone Advisory Board. Sangeetha Shyam has received consulting fees from Abbott Sdn Bhd. Stephanie K. Nishi is a volunteer member of Plant-Based Canada, a non-profit organization. Other authors (Jesús Francisco García-Gavilán, Indira Paz-Graniel, José J Gaforio4 Miguel Ángel Martínez-González, Dolores Corella, J. Alfredo Martínez, Ángel M. Alonso-Gómez, Julia Wärnberg, Jesús Vioque, Dora Romaguera, José López-Miranda, Francisco J Tinahones, José Lapetra, J. Luís Serra-Majem, Aurora Bueno-Cavanillas, Josep A. Tur, Vicente Martín Sánchez, Xavier Pintó, Pilar Matía-Martín, Josep Vidal, María del Mar Alcarria, Lidia Daimiel, Óscar García Regata, Rafael Perez Araluce, Eva M Asensio, Olga Castañer, Antonio Garcia-Rios, Alejandro Oncina-Cánovas, Cristina Bouzas, M. Angeles Zulet, Elena Rayó, Rosa Casas1,16,17, Sandra Martin-Pelaez, Lucas Tojal-Sierra, Bernal-López MR, Silvia Carlos, Jose V.Sorlí, Albert Goday, Patricia J. Peña-Orihuela, Ana Pastor-Morel, Sonia Eguaras, María Dolors Zomeño, Miguel Delgado-Rodríguez, Nancy Babio, and Montserrat Fitó) declared no potential conflict of interest.
Databáze: MEDLINE
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