The Global Impact of COVID-19: Historical Development, Molecular Characterization, Drug Discovery and Future Directions.

Autor: Dofuor AK; Department of Biological Sciences, School of Natural and Environmental Sciences, University of Environment and Sustainable Development, Somanya, Ghana., Quartey NK; Department of Food Science and Technology, Faculty of Biosciences, College of Science, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana., Osabutey AF; Department of Agribusiness, School of Business, Presbyterian University, Abetifi-Kwahu, Ghana., Boateng BO; Coconut Research Program, Oil Palm Research Institute, Council for Scientific and Industrial Research, Sekondi-Takoradi, Ghana., Lutuf H; Crop Protection Division, Oil Palm Research Institute, Council for Scientific and Industrial Research, Kade, Ghana., Osei JHN; Department of Parasitology, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Legon, Accra, Ghana., Ayivi-Tosuh SM; Department of Biochemistry, School of Life Sciences, Northeast Normal University, Changchun, Jilin Province, China., Aiduenu AF; West African Centre for Cell Biology of Infectious Pathogens, University of Ghana, Legon, Accra, Ghana., Ekloh W; Department of Biochemistry, School of Biological Sciences, College of Agriculture and Natural Sciences, University of Cape Coast, Cape Coast, Ghana., Loh SK; Department of Built Environment, School of Sustainable Development, University of Environment and Sustainable Development, Somanya, Ghana., Opoku MJ; Department of Biological Sciences, School of Natural and Environmental Sciences, University of Environment and Sustainable Development, Somanya, Ghana., Aidoo OF; Department of Biological Sciences, School of Natural and Environmental Sciences, University of Environment and Sustainable Development, Somanya, Ghana.
Jazyk: angličtina
Zdroj: Clinical pathology (Thousand Oaks, Ventura County, Calif.) [Clin Pathol] 2023 Dec 23; Vol. 16, pp. 2632010X231218075. Date of Electronic Publication: 2023 Dec 23 (Print Publication: 2023).
DOI: 10.1177/2632010X231218075
Abstrakt: In December 2019, an outbreak of a respiratory disease called the coronavirus disease 2019 (COVID-19) caused by a new coronavirus known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) began in Wuhan, China. The SARS-CoV-2, an encapsulated positive-stranded RNA virus, spread worldwide with disastrous consequences for people's health, economies, and quality of life. The disease has had far-reaching impacts on society, including economic disruption, school closures, and increased stress and anxiety. It has also highlighted disparities in healthcare access and outcomes, with marginalized communities disproportionately affected by the SARS-CoV-2. The symptoms of COVID-19 range from mild to severe. There is presently no effective cure. Nevertheless, significant progress has been made in developing COVID-19 vaccine for different therapeutic targets. For instance, scientists developed multifold vaccine candidates shortly after the COVID-19 outbreak after Pfizer and AstraZeneca discovered the initial COVID-19 vaccines. These vaccines reduce disease spread, severity, and mortality. The addition of rapid diagnostics to microscopy for COVID-19 diagnosis has proven crucial. Our review provides a thorough overview of the historical development of COVID-19 and molecular and biochemical characterization of the SARS-CoV-2. We highlight the potential contributions from insect and plant sources as anti-SARS-CoV-2 and present directions for future research.
Competing Interests: The authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
(© The Author(s) 2023.)
Databáze: MEDLINE
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