A Double Hit of Social and Economic Stress in Mice Precipitates Changes in Decision-Making Strategies.

Autor: Durand-de Cuttoli R; Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York., Martínez-Rivera FJ; Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York., Li L; Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York., Minier-Toribio A; Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York., Dong Z; Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York., Cai DJ; Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York., Russo SJ; Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York., Nestler EJ; Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York; Department of Psychiatry, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York., Sweis BM; Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York; Department of Psychiatry, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York. Electronic address: brian.sweis@mountsinai.org.
Jazyk: angličtina
Zdroj: Biological psychiatry [Biol Psychiatry] 2024 Jul 01; Vol. 96 (1), pp. 67-78. Date of Electronic Publication: 2023 Dec 21.
DOI: 10.1016/j.biopsych.2023.12.011
Abstrakt: Background: Economic stress can serve as a second hit for people who have already accumulated a history of adverse life experiences. How one recovers from a setback is a core feature of resilience but is seldom captured in animal studies.
Methods: We challenged mice in a novel 2-hit stress model by first exposing them to chronic social defeat stress and then testing adaptations to increasing reward scarcity on a neuroeconomic task. Mice were tested across months on the Restaurant Row task, during which they foraged daily for their primary source of food while on a limited time budget in a closed-economy system. An abrupt transition into a reward-scarce environment elicits an economic challenge, precipitating a drop in food intake and body weight to which mice must respond to survive.
Results: We found that mice with a history of social stress mounted a robust behavioral response to this economic challenge that was achieved through a complex redistribution of time allocation among competing opportunities. Interestingly, we found that mice with a history of social defeat displayed changes in the development of decision-making policies during the recovery process that are important not only for ensuring food security necessary for survival but also prioritizing subjective value and that these changes emerged only for certain types of choices.
Conclusions: These findings indicate that an individual's capacity to recover from economic challenges depends on that person's prior history of stress and can affect multiple decision-making aspects of subjective well-being, thus highlighting a motivational balance that may be altered in stress-related disorders such as depression.
(Copyright © 2023 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: