Changes in Adiposity and Cognitive Function in Older Adults: The REGARDS Study.

Autor:	Zhu W; School of Physical Education, Shaanxi Normal University, Xi'an, Shaanxi, China., Li Y; School of Physical Education, Shaanxi Normal University, Xi'an, Shaanxi, China., Zhao C; School of Physical Education, Shaanxi Normal University, Xi'an, Shaanxi, China., Howard VJ; Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama, USA., Wadley VG; Department of Medicine, School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA., Judd SE; Department of Biostatistics, School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama, USA., Colabianchi N; School of Kinesiology, University of Michigan, Ann Arbor, Michigan, USA., McClure LA; College for Public Health and Social Justice, Saint Louis University, Saint Louis, Missouri, USA., Hooker SP; College of Health and Human Services, San Diego State University, San Diego, California, USA., Sun Y; School of Physical Education, Shaanxi Normal University, Xi'an, Shaanxi, China.
Jazyk:	angličtina
Zdroj:	The journals of gerontology. Series B, Psychological sciences and social sciences [J Gerontol B Psychol Sci Soc Sci] 2024 Mar 01; Vol. 79 (3).
DOI:	10.1093/geronb/gbad184
Abstrakt:	Objectives: Adiposity may have a role in the risk of dementia. Fewer studies have focused on the relationship between change in adiposity and cognitive decline. Our study aimed to explore the association between the change in adiposity and cognitive function in Black and White older adults. Methods: The participants were 12,204 older adults without cognitive impairment (62.8 ± 8.0 years) in the United States. The percent body mass index change (%BMI change) and percent waist circumference change (%WC change) were measured at 2 in-home visits (first: 2003-2007, second: 2013-2016). Cognitive status was assessed by the Six-Item Screener annually. Memory and executive function were measured by word list learning, MOCA recall and orientation, and letter and animal fluency every 2 years. Logistic regression or linear regression models were used to estimate the relationship between percent change in adiposity and cognitive function. Results: After 12.7 ± 1.7 years, a greater decrease in %BMI change or %WC change was significantly associated with a higher risk of cognitive impairment. Compared to older adults with -5% ≤ change ≤ 5% from baseline, a significantly higher risk of cognitive impairment and greater loss in memory and executive function were found among those who experienced more than a 10% decline in %BMI change or %WC change. Older adults who experienced a 5%-10% decrease in %BMI change had a higher risk of cognitive impairment and greater loss of memory compared to those with -5% ≤ change ≤ 5%. Discussion: A greater decrease in %BMI (>5%) and %WC (>10%) change was associated with greater cognitive loss observed over time. (© The Author(s) 2023. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
Databáze:	MEDLINE
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