| Autor: |
Souza VGP; British Columbia Cancer Research Institute, Vancouver, BC V5Z 1L3, Canada.; Molecular Oncology Laboratory, Experimental Research Unit, School of Medicine, São Paulo State University (UNESP), Botucatu 18618-687, SP, Brazil., Forder A; British Columbia Cancer Research Institute, Vancouver, BC V5Z 1L3, Canada., Pewarchuk ME; British Columbia Cancer Research Institute, Vancouver, BC V5Z 1L3, Canada., Telkar N; British Columbia Cancer Research Institute, Vancouver, BC V5Z 1L3, Canada.; British Columbia Children's Hospital Research Institute, Vancouver, BC V5Z 4H4, Canada., de Araujo RP; Molecular Oncology Laboratory, Experimental Research Unit, School of Medicine, São Paulo State University (UNESP), Botucatu 18618-687, SP, Brazil., Stewart GL; British Columbia Cancer Research Institute, Vancouver, BC V5Z 1L3, Canada., Vieira J; British Columbia Cancer Research Institute, Vancouver, BC V5Z 1L3, Canada., Reis PP; Molecular Oncology Laboratory, Experimental Research Unit, School of Medicine, São Paulo State University (UNESP), Botucatu 18618-687, SP, Brazil.; Department of Surgery and Orthopedics, Faculty of Medicine, São Paulo State University (UNESP), Botucatu 18618-687, SP, Brazil., Lam WL; British Columbia Cancer Research Institute, Vancouver, BC V5Z 1L3, Canada. |
| Abstrakt: |
In recent years, there has been a growing interest in the relationship between microorganisms in the surrounding environment and cancer cells. While the tumor microenvironment predominantly comprises cancer cells, stromal cells, and immune cells, emerging research highlights the significant contributions of microbial cells to tumor development and progression. Although the impact of the gut microbiome on treatment response in lung cancer is well established, recent investigations indicate complex roles of lung microbiota in lung cancer. This article focuses on recent findings on the human lung microbiome and its impacts in cancer development and progression. We delve into the characteristics of the lung microbiome and its influence on lung cancer development. Additionally, we explore the characteristics of the intratumoral microbiome, the metabolic interactions between lung tumor cells, and how microorganism-produced metabolites can contribute to cancer progression. Furthermore, we provide a comprehensive review of the current literature on the lung microbiome and its implications for the metastatic potential of tumor cells. Additionally, this review discusses the potential for therapeutic modulation of the microbiome to establish lung cancer prevention strategies and optimize lung cancer treatment. |
