Comparison of the clinical features and outcomes of severe seasonal influenza and COVID-19 patients in Tunisia between 2021 and 2022.

Autor: Ben Khelil J; Intensive Care Department Abderrahman Mami Hospital Ariana Tunisia.; Faculty of Medicine of Tunis University of Tunis El Manar Tunis Tunisia.; Research Unit for Respiratory Failure and Mechanical Ventilation UR22SP01 Abderrahman Mami Hospital Ariana Tunisia., Yazidi R; Service of Medical Epidemiology Institut Pasteur de Tunis Tunis-Belvédère Tunisia.; Laboratory of Transmission, Control and Immunobiology of Infections (LR16IPT02); Institut Pasteur de Tunis Tunis-Belvédère Tunisia., Ben Mrad N; Intensive Care Department Abderrahman Mami Hospital Ariana Tunisia.; Faculty of Medicine of Tunis University of Tunis El Manar Tunis Tunisia.; Research Unit for Respiratory Failure and Mechanical Ventilation UR22SP01 Abderrahman Mami Hospital Ariana Tunisia., Jarraya F; Intensive Care Department Abderrahman Mami Hospital Ariana Tunisia.; Faculty of Medicine of Tunis University of Tunis El Manar Tunis Tunisia.; Research Unit for Respiratory Failure and Mechanical Ventilation UR22SP01 Abderrahman Mami Hospital Ariana Tunisia., Rachdi E; Intensive Care Department Abderrahman Mami Hospital Ariana Tunisia.; Faculty of Medicine of Tunis University of Tunis El Manar Tunis Tunisia.; Research Unit for Respiratory Failure and Mechanical Ventilation UR22SP01 Abderrahman Mami Hospital Ariana Tunisia., Ayed S; Intensive Care Department Abderrahman Mami Hospital Ariana Tunisia.; Faculty of Medicine of Tunis University of Tunis El Manar Tunis Tunisia.; Research Unit for Respiratory Failure and Mechanical Ventilation UR22SP01 Abderrahman Mami Hospital Ariana Tunisia., Jamoussi A; Intensive Care Department Abderrahman Mami Hospital Ariana Tunisia.; Faculty of Medicine of Tunis University of Tunis El Manar Tunis Tunisia.; Research Unit for Respiratory Failure and Mechanical Ventilation UR22SP01 Abderrahman Mami Hospital Ariana Tunisia., Ben Salah A; Laboratory of Transmission, Control and Immunobiology of Infections (LR16IPT02); Institut Pasteur de Tunis Tunis-Belvédère Tunisia.; Department of Family and Community Medicine, College of Medicine and Medical Sciences (CMMS) Arabian Gulf University (AGU) Manama Bahrain., Besbes M; Intensive Care Department Abderrahman Mami Hospital Ariana Tunisia.; Faculty of Medicine of Tunis University of Tunis El Manar Tunis Tunisia.; Research Unit for Respiratory Failure and Mechanical Ventilation UR22SP01 Abderrahman Mami Hospital Ariana Tunisia.
Jazyk: angličtina
Zdroj: Influenza and other respiratory viruses [Influenza Other Respir Viruses] 2023 Dec 20; Vol. 17 (12), pp. e13215. Date of Electronic Publication: 2023 Dec 20 (Print Publication: 2023).
DOI: 10.1111/irv.13215
Abstrakt: Background: We compared patients diagnosed at a SARI (severe acute respiratory infections) surveillance site with COVID-19 and those with seasonal influenza to investigate the clinical differences, common features, and outcomes.
Methods: We conducted a descriptive, retrospective study in the Medical Intensive Care Unit (ICU) at Abderrahman Mami Hospital between September 2021 and April 2022. Demographic, clinical, and biological data as well as outcomes were recorded for all patients.
Results: Among 223 SARI patients, 83 were confirmed COVID-19, and 22 were influenza positive. The distribution according to gender was similar; but patients with influenza were younger than those suffering from COVID-19(mean age 60.36 SD 17.28 vs. 61.88 SD 17.91; P = 0.601). In terms of underlying chronic diseases, the frequency was 84.3% in the COVID-19 group and 72.7% in the influenza group. COVID-19 patients had a longer duration of hospitalization (mean [SD], 9.51 days [8.47 days] vs. 7.33 days [8.82 days]; P = 0.003), and a more frequent need for invasive ventilation (80 [97.4%] vs. 20 [92.3]). Case fatality was also higher among this group compared to the latter (39 [47%] vs. 6 [27.3%], P = 0.01).
Conclusion: This exploratory study suggests higher severity of COVID-19 compared to seasonal influenza among SARI hospitalized patients even during the Omicron wave. Further research on higher sample sizes is required to confirm this conclusion.
Competing Interests: The authors declare that they have no competing interests.
(© 2023 The Authors. Influenza and Other Respiratory Viruses published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
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